Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Laser-induced Forward Transfer for Flip-chip Packaging of Single Dies

Laser-induced Forward Transfer for Flip-chip Packaging of Single Dies

We demonstrate the use of the Laser-induced Forward Transfer (LIFT) technique for flip-chip assembly of optoelectronic components. This approach provides a simple, cost-effective, low-temperature, fast and flexible solution for fine-pitch bumping and bonding on chip-scale for achieving high-density circuits for optoelectronic...

Kubler Ross's Stages of Dying

Kubler Ross's Stages of Dying

Elisabeth Kübler-Ross significantly advanced psychology's understanding of the process of dying with her influential book, On Death and Dying (1969). She focused on studying terminally ill individuals and outlined five stages commonly experienced when coping with death: denial, anger, bargaining, depression, and acceptance.
In denial, individuals reject the reality of their condition, often thinking, "This isn't true; I feel fine," as a way to protect themselves from...

Law of Segregation

Law of Segregation

When crossing pea plants, Mendel noticed that one of the parental traits would sometimes disappear in the first generation of offspring, called the F1 generation, and could reappear in the next generation (F2). He concluded that one of the traits must be dominant over the other, thereby causing masking of one trait in the F1 generation. When he crossed the F1 plants, he found that 75% of the offspring in the F2 generation had the dominant phenotype, while 25% had the recessive phenotype.

Segregation in Fresh Concrete

Segregation in Fresh Concrete

Segregation in fresh concrete is a phenomenon where the components of the concrete mix separate, leading to uneven distribution and compromised structural integrity. This separation typically occurs when concrete is subjected to excessive horizontal movement within forms, or when it is dropped from considerable heights or forced through narrow, winding paths. As a result, heavier coarse aggregate particles settle at the bottom, while lighter, finer materials such as cement and water rise to the...

Finding Your Blind Spot and Perceptual Filling-in

Finding Your Blind Spot and Perceptual Filling-in

Source: Laboratory of Jonathan Flombaum—Johns Hopkins University
In the back of everyone's eye is a small piece of neural tissue called the retina. The retina has photosensitive cells that respond to stimulation by light. The responses of these cells are sent into the brain through the optic nerve, a bundle of neural fibers. In each retina there is a place somewhere in the periphery where the outputs from retinal cells collect and the bundled optic nerve exits to the brain. At that...

Live Cell Imaging of Chromosome Segregation During Mitosis

Live Cell Imaging of Chromosome Segregation During Mitosis

This protocol describes an easy and convenient method to label and visualize live chromosomes in mitotic cells using Histone2B-GFP BacMam 2.0 label and a spinning disc confocal microscopy...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Examining Wang Jiufeng and his works].

Zhonghua yi shi za zhi (Beijing, China : 1980)·2026

Same author

[Tuberous sclerosis complex-associated multifocal micronodular pneumocyte hyperplasia: a clinicopathological features and TSC1/TSC2 gene mutation analysis of eight cases].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026

Same author

First Detection of Ultrahigh Energy Emission from Gamma-Ray Binary LS I +61° 303.

Physical review letters·2026

Same author

Evidence of Cosmic-Ray Acceleration up to Sub-PeV Energies in the Supernova Remnant IC 443.

Physical review letters·2026

Same author

[The interpretation of pathological content in the 2025 ERS/ATS international multidisciplinary classification of interstitial pneumonia].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026

Same author

Precise Measurement of the Cosmic Ray Helium Spectrum above 0.1 PeV.

Physical review letters·2026

Search research articles

Related Experiment Video

Updated: Jan 19, 2026

Laser-induced Forward Transfer for Flip-chip Packaging of Single Dies

Laser-induced Forward Transfer for Flip-chip Packaging of Single Dies

Published on: March 20, 2015

Size-induced segregation during die filling.

A Zakhvatayeva¹, C Hare¹, C Y Wu¹

¹Department of Chemical and Process Engineering, University of Surrey, Guildford GU2 7XH, UK.

International Journal of Pharmaceutics: X

|September 19, 2019

Summary

This summary is machine-generated.

Particle size segregation in pharmaceutical blends was studied during die filling. Suction filling at low velocity minimized segregation, while gravity filling showed higher tendencies due to air drag and cascading effects.

Keywords:

Die filling Particle size Powder flow Segregation Tabletting

More Related Videos

Live Cell Imaging of Chromosome Segregation During Mitosis

Live Cell Imaging of Chromosome Segregation During Mitosis

Published on: March 14, 2018

Monitoring Spatial Segregation in Surface Colonizing Microbial Populations

Monitoring Spatial Segregation in Surface Colonizing Microbial Populations

Published on: October 29, 2016

Related Experiment Videos

Last Updated: Jan 19, 2026

Laser-induced Forward Transfer for Flip-chip Packaging of Single Dies

Laser-induced Forward Transfer for Flip-chip Packaging of Single Dies

Published on: March 20, 2015

Live Cell Imaging of Chromosome Segregation During Mitosis

Live Cell Imaging of Chromosome Segregation During Mitosis

Published on: March 14, 2018

Monitoring Spatial Segregation in Surface Colonizing Microbial Populations

Monitoring Spatial Segregation in Surface Colonizing Microbial Populations

Published on: October 29, 2016

Area of Science:

Pharmaceutical Science
Powder Technology
Materials Science

Background:

Particle size distribution significantly impacts powder blend uniformity.
Segregation during die filling can compromise pharmaceutical product quality and efficacy.
Understanding segregation mechanisms is crucial for robust pharmaceutical manufacturing processes.

Purpose of the Study:

To investigate particle size-induced segregation in binary pharmaceutical blends during die filling.
To evaluate the influence of filling methods (gravity vs. suction) and velocities on segregation.
To determine the primary mechanisms driving segregation in pharmaceutical powder blends.

Main Methods:

Binary blends of acetylsalicylic acid (coarse) and mannitol (fine) were prepared.
Die filling was performed using gravity and suction methods at varying velocities.
Coarse component concentration was measured using UV-Visible spectrophotometry.
Segregation Index (SI) was calculated to quantify blend uniformity.

Main Results:

High segregation tendency was observed during low-velocity gravity filling (air drag) and high-velocity gravity filling (multi-step filling).
Suction filling at low velocity exhibited the lowest segregation tendency.
Horizontal segregation predominantly occurred in the upper die layers via cascading mechanisms.

Conclusions:

Filling method and velocity are critical parameters influencing particle segregation in pharmaceutical blends.
Suction filling offers a potentially more uniform powder deposition compared to gravity filling.
Segregation mechanisms, particularly particle cascading, must be considered during die filling optimization.