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Updated: Jan 19, 2026
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α-C-H borylation of secondary alcohols via Ru/Fe relay catalysis: building a platform for alcoholic C-H/C-O
1State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences, Lanzhou 730000, P. R. China. chaoliu@licp.cas.cn and University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
Abstract:
An unprecedented α-C-H borylation of secondary alcohols was successfully achieved and delivered various tertiary α-boryl alcohols via [Ru]/[Fe] relay catalysis. The dehydrogenation catalyst (Ru) and borylation catalyst (Fe) interacted to increase the chemoselectivity. By installing the "platform functional group" Bpin via this α-C-H borylation, several alcoholic α-C-H and C-O bond functionalizations were successfully achieved.
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