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Updated: Jan 19, 2026

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules
Published on: June 1, 2011
A catalytic DNA circuit-programmed and enzyme-powered autonomous DNA machine for nucleic acid detection
Shuang Liu1, Chen Xin, Xiaoxiao Yu
1Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 53 Zhengzhou Road, Qingdao 266042, China. sliu@qust.edu.cn.
Abstract:
A catalytic DNA circuit was ingeniously engineered to harness the cleavage of a nicking endonuclease on a triple-stranded duplex DNA probe, autonomously actuating a successive enzyme-powered DNA machine for one-step, isothermal, and autocatalytic nucleic acid analysis. The detection performance could be tuned with or without the use of enzymes.
Related Concept Videos
13:15Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules
Nucleic Acids
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
Nucleic acids
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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