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Related Concept Videos

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model05:12

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

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This protocol demonstrates the induction of cerebral cavernous malformation disease in a mouse model and uses contrast enhanced micro computed tomography to measure lesion burden. This method enhances the value of established mouse models to study the molecular basis and potential therapies for cerebral cavernous malformation and other cerebrovascular...
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In this video, a genetically modified mouse pup carrying the Ccm2 gene flanked by loxP sites and Cre recombinase fused to an estrogen receptor is used to induce cerebral cavernous malformations (CCMs). The administration of 4-hydroxytamoxifen activates Cre in endothelial cells, leading to the deletion of Ccm2 and the formation of CCMs in the...
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Source: Choi, J. P. et al. Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model. J. Vis. Exp. (2017)This video demonstrates the use of micro-CT imaging to visualize cerebral cavernous malformation (CCM) lesions in a mouse brain. It details the steps for sample preparation, imaging, and 3D image reconstruction to evaluate the density and location of CCM lesions in brain...
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Cavernous Nerve Stimulation and Recording of Intracavernous Pressure in a Rat07:43

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Related Experiment Video

Updated: Jan 19, 2026

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model
05:12

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

Published on: September 4, 2017

11.3K

Giant Cervical Cavernous Malformation: 2-Dimensional Operative Video.

Benjamin K Hendricks1, Robert F Spetzler1

  • 1Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona.

Operative Neurosurgery (Hagerstown, Md.)
|September 19, 2019
PubMed
Summary

Symptomatic cervical spinal cord cavernous malformations require surgical removal. Gross total resection prevents further neurological decline from hemorrhage, as demonstrated in this case of a large high cervical lesion.

Keywords:
Cavernous malformationIntraduralLaminoplastyMicrosurgical

More Related Videos

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Contrast-Enhanced Micro-CT Imaging of Cerebral Cavernous Malformation Lesions in a Mouse Brain
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Contrast-Enhanced Micro-CT Imaging of Cerebral Cavernous Malformation Lesions in a Mouse Brain

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Related Experiment Videos

Last Updated: Jan 19, 2026

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model
05:12

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

Published on: September 4, 2017

11.3K
Cre-LoxP Mediated Induction of Cerebral Cavernous Malformations in a Mouse Model
01:59

Cre-LoxP Mediated Induction of Cerebral Cavernous Malformations in a Mouse Model

506
Contrast-Enhanced Micro-CT Imaging of Cerebral Cavernous Malformation Lesions in a Mouse Brain
03:35

Contrast-Enhanced Micro-CT Imaging of Cerebral Cavernous Malformation Lesions in a Mouse Brain

Published on: May 29, 2025

639

Area of Science:

  • Neurosurgery
  • Neurology
  • Spinal Cord Surgery

Background:

  • Cervical spinal cord cavernous malformations are rare, potentially devastating lesions.
  • Symptomatic lesions necessitate intervention to prevent progressive neurological deficits from recurrent hemorrhage.

Purpose of the Study:

  • To describe the surgical management of a large, high cervical spinal cord cavernous malformation.
  • To illustrate the technique for gross total resection and preservation of neurological function.

Main Methods:

  • Surgical resection of a large, high cervical spinal cord cavernous malformation.
  • Utilized a midline myelotomy for lesion access.
  • Performed piecemeal removal after circumferential separation from spinal parenchyma.

Main Results:

  • Achieved gross total resection of the cervical spinal cord cavernous malformation.
  • Postoperative imaging confirmed complete removal of the lesion.
  • Preservation of the surrounding spinal cord tissue was achieved.

Conclusions:

  • Gross total resection is the optimal treatment for symptomatic cervical spinal cord cavernous malformations.
  • Surgical intervention can prevent further neurological decline associated with these lesions.
  • Minimally invasive techniques can achieve successful resection with preserved function.