Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

High-speed Particle Image Velocimetry Near Surfaces11:59

High-speed Particle Image Velocimetry Near Surfaces

33.8K
A procedure for studying transient flows near boundaries using high-resolution, high-speed particle image velocimetry (PIV) is described here. PIV is a non-intrusive measurement technique applicable to any optically accessible flow by optimizing several parameter constraints such as the image and recording properties, the laser sheet properties, and analysis...
33.8K
Simulating Imaging of Large Scale Radio Arrays on the Lunar Surface06:14

Simulating Imaging of Large Scale Radio Arrays on the Lunar Surface

5.3K
A simulation framework for testing the imaging capabilities of large-scale radio arrays on the lunar surface is presented. Major noise components are discussed, and a software pipeline is walked through with details on how to customize it for novel scientific...
5.3K
Transport of Surface-modified Carbon Nanotubes through a Soil Column10:26

Transport of Surface-modified Carbon Nanotubes through a Soil Column

9.9K
Surface properties of a nanoparticle are important for their interaction with the surrounding medium. Therefore the surface modification of carbon nanotubes can be critical for their transport and retention through porous media. Here, lab scale column experiments are used to understand the possible transport and retention of these nanoparticles.
9.9K
Regulated mRNA Transport02:22

Regulated mRNA Transport

6.9K
In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
6.9K
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

1.6K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.6K
Detection of the Surface Metal Transporters in Neisseria gonorrhoeae Using Dot Blot03:08

Detection of the Surface Metal Transporters in Neisseria gonorrhoeae Using Dot Blot

171
Source: Maurakis, S., and Cornelissen, C. N. Metal-Limited Growth of Neisseria gonorrhoeae for Characterization of Metal-Responsive Genes and Metal Acquisition from Host Ligands. J. Vis. Exp. (2020)This video demonstrates the procedure for detecting surface metal transporters in Neisseria gonorrhoeae grown under metal-limited conditions using a dot blot assay, involving ligand binding, antibody detection, and colorimetric...
171

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Computational fluid dynamics of cerebral aneurysm coiling using high-resolution and high-energy synchrotron X-ray microtomography: comparison with the homogeneous porous medium approach.

Journal of neurointerventional surgery·2016
Same author

Convective Leakage Makes Heparin Locking of Central Venous Catheters Ineffective Within Seconds: Experimental Measurements in a Model Superior Vena Cava.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2015
Same author

A modification of Murray's law for shear-thinning rheology.

Journal of biomechanical engineering·2015
Same author

Leakage of central venous catheter locking fluid by hemodynamic transport.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2014
Same author

Accuracy of computational cerebral aneurysm hemodynamics using patient-specific endovascular measurements.

Annals of biomedical engineering·2013
Same author

Effects of wall distensibility in hemodynamic simulations of an arteriovenous fistula.

Biomechanics and modeling in mechanobiology·2013

Related Experiment Video

Updated: Jan 19, 2026

High-speed Particle Image Velocimetry Near Surfaces
11:59

High-speed Particle Image Velocimetry Near Surfaces

Published on: June 24, 2013

33.8K

Embolus Transport Simulations with Fully Resolved Particle Surfaces.

Patrick M McGah1

  • 1Siemens PLM Software Inc., 13810 SE Eastgate Way, Bellevue, WA, 98005, USA. patrick.mcgah@siemens.com.

Cardiovascular Engineering and Technology
|September 19, 2019
PubMed
Summary

Computational fluid dynamics simulations show that larger emboli (≥20% of vessel diameter) require resolved particle models for accurate trajectory analysis. This finding is crucial for understanding stroke risk and improving embolus simulations.

More Related Videos

Simulating Imaging of Large Scale Radio Arrays on the Lunar Surface
06:14

Simulating Imaging of Large Scale Radio Arrays on the Lunar Surface

Published on: July 30, 2020

5.3K
Transport of Surface-modified Carbon Nanotubes through a Soil Column
10:26

Transport of Surface-modified Carbon Nanotubes through a Soil Column

Published on: April 2, 2015

9.9K

Related Experiment Videos

Last Updated: Jan 19, 2026

High-speed Particle Image Velocimetry Near Surfaces
11:59

High-speed Particle Image Velocimetry Near Surfaces

Published on: June 24, 2013

33.8K
Simulating Imaging of Large Scale Radio Arrays on the Lunar Surface
06:14

Simulating Imaging of Large Scale Radio Arrays on the Lunar Surface

Published on: July 30, 2020

5.3K
Transport of Surface-modified Carbon Nanotubes through a Soil Column
10:26

Transport of Surface-modified Carbon Nanotubes through a Soil Column

Published on: April 2, 2015

9.9K

Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Medical Imaging

Background:

  • Hemodynamic factors influence emboli trajectory and stroke risk.
  • Previous models often assumed "small" particles, limiting accuracy for larger emboli.
  • This study addresses the limitations of the "small" particle assumption in embolus simulations.

Purpose of the Study:

  • To quantify the threshold at which emboli can no longer be considered "small" in vascular simulations.
  • To compare particle trajectories using "small" particle models versus fully resolved models.
  • To assess the impact of particle size on embolus fate in patient-specific models.

Main Methods:

  • Utilized computational fluid dynamics with an overset mesh technique for accurate fluid stress resolution.
  • Simulated embolus-like particles of varying sizes (500, 1000, 2000 μm) in a patient-specific carotid artery bifurcation model.
  • Compared particle trajectories and proportions entering the internal carotid artery between "small" and resolved particle models.

Main Results:

  • For 2000 μm emboli (27% of vessel diameter), the resolved model showed a statistically significant increase in particles reaching the internal carotid artery (85.7% vs. 74.7%).
  • No significant differences were observed for smaller particle diameters.
  • Quantitative differences in trajectories were evident for the largest resolved particles.

Conclusions:

  • A fully resolved particle model is necessary for embolus trajectory simulations when particle size is approximately 20% or greater of the vessel diameter.
  • This finding refines the "small" particle assumption, improving the accuracy of stroke risk assessment.
  • Emphasizes the importance of considering particle size in computational fluid dynamics models of vascular transport.