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The motion regimes of ibuprofen encapsulated in β-cyclodextrin nanosponges polymer network are investigated using pulsed-field-gradient spin-echo (PGSE) NMR technique. Synthesis, purification, drug loading, implementation of the NMR pulse sequence and data analysis to work out the mean square displacement of the drug at several observation times are described in...
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Related Experiment Video

Updated: Jan 19, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Loading-Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid-State NMR Spectroscopy.

Ann-Christin Pöppler1, Michael M Lübtow2, Jonas Schlauersbach3

  • 1Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.

Angewandte Chemie (International Ed. in English)
|September 19, 2019
PubMed
Summary

Higher curcumin loading in poly(2-oxazoline) and poly(2-oxazine) micelles worsens dissolution. A loading-dependent structural model reveals interactions shift from hydrophobic to hydrophilic polymer blocks, crucial for optimizing drug delivery systems.

Keywords:
dissolution ratesmicellespolymersshort-range ordersolid-state NMR spectroscopy

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Drug Delivery

Background:

  • Understanding the internal structure of drug-loaded polymeric micelles is crucial for effective drug delivery.
  • Current knowledge on the molecular-level organization within these micelles, especially concerning drug loading, is limited.
  • Polymeric micelles based on poly(2-oxazolines) and poly(2-oxazines) are investigated for their drug encapsulation properties.

Purpose of the Study:

  • To elucidate the loading-dependent structural changes in curcumin-loaded poly(2-oxazoline) and poly(2-oxazine) micelles.
  • To correlate these structural changes with the observed dissolution properties.
  • To develop a molecular-level model explaining the influence of drug loading on micelle architecture.

Main Methods:

  • Solid-state Nuclear Magnetic Resonance (NMR) spectroscopy, including 2D NMR experiments.
  • Complementary analytical techniques to assess micelle structure and properties.
  • Curcumin loading and dissolution studies of triblock copolymers.

Main Results:

  • Increased curcumin loading led to diminished dissolution properties of the polymeric micelles.
  • Solid-state NMR revealed a shift in curcumin's interaction site within the micelle structure.
  • At low loadings, curcumin interacted primarily with the hydrophobic polymer blocks.
  • At higher loadings, curcumin increasingly interacted with the hydrophilic polymer blocks.

Conclusions:

  • A loading-dependent structural model for curcumin-loaded polymeric micelles was proposed.
  • The shift in interaction from hydrophobic to hydrophilic blocks explains the observed differences in dissolution.
  • Understanding these hydrophilic interactions is key for designing ultrahigh-loaded micelles and improving drug delivery systems.