Useful prognostic tools based on complete blood cell counts in diffuse large B-cell lymphoma.

Area of Science:

• Hematology
• Oncology
• Clinical Pathology

Background:

• Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma.
• Current prognostic models include the International Prognostic Index (IPI), Revised-IPI (R-IPI), and National Comprehensive Cancer Network-IPI (NCCN-IPI).

Purpose of the Study:

• To develop a prognostic model for DLBCL utilizing readily available complete blood cell count (CBC) parameters.
• To assess the predictive value of lymphocyte-to-monocyte ratio (LMR), hemoglobin, and platelet counts in DLBCL prognosis.

Main Methods:

• A prognostic model was developed using CBC data (LMR, hemoglobin, platelets) from 214 DLBCL patients treated with R-CHOP therapy.
• Receiver operating characteristic (ROC) curve analysis determined cutoff values for LMR (1.6), hemoglobin (100 g/L), and platelets (150 × 10^9/L).
• Patients were stratified into three groups based on the presence of these factors.

Main Results:

• The 5-year overall survival (OS) rates for the three CBC groups were 78.2%, 60.9%, and 10.1%.
• Multivariate analysis identified the presence of all three factors (CBC Group 3) as a significant prognostic factor for OS (HR, 2.976; P = .01).
• CBC Group 3 enabled further stratification within existing high-risk IPI and R-IPI groups.

Conclusions:

• A combination of three CBC parameters (LMR, hemoglobin, platelets) shows potential as a valuable prognostic tool in DLBCL.
• This simple CBC-based model can aid in identifying and stratifying patients with poor prognoses.