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1,25(OH)2D and 24,25(OH)2D production in the developing kidney.

M Ishida1, M Shima, Y Seino

  • 1Department of Pediatrics, Osaka University School of Medicine, Japan.

Pediatric Nephrology (Berlin, Germany)
|January 1, 1988
PubMed
Summary

Vitamin D production in the developing kidney is influenced by the fetus and newborn. Kidney 1 alpha-hydroxylase activity is highest in young rats, decreasing with age.

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Area of Science:

  • Endocrinology
  • Developmental Biology
  • Nephrology

Background:

  • Vitamin D is crucial for calcium homeostasis and bone health.
  • The developing kidney plays a role in vitamin D metabolism.
  • Understanding age-related changes in vitamin D production is vital for pediatric and maternal health.

Purpose of the Study:

  • To investigate vitamin D production in the developing kidney across different human age groups.
  • To determine the age-dependent activity of key vitamin D-hydroxylating enzymes in the kidney.

Main Methods:

  • Serum levels of 1,25(OH)2D and 24,25(OH)2D were measured in human subjects of various ages.
  • Kidney mitochondrial 1 alpha-hydroxylase and 24-hydroxylase activities were assessed in rats at different ages.

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Main Results:

  • Serum 1,25(OH)2D levels were significantly higher in pregnant women, cord blood, and newborns compared to older children and adults.
  • Newborn 1,25(OH)2D levels correlated positively with gestational age.
  • Kidney 1 alpha-hydroxylase activity in rats peaked in young (1-2 months) individuals and declined with age, primarily due to changes in Vmax.

Conclusions:

  • Fetal and neonatal factors significantly contribute to vitamin D synthesis, not solely maternal influence.
  • Kidney 1 alpha-hydroxylase activity undergoes significant developmental changes, peaking in early life.
  • These findings highlight the dynamic nature of vitamin D metabolism during development.