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Updated: Jan 19, 2026

A Mouse Model of Fatigue Induced by Peripheral Irradiation
Published on: March 17, 2017
[Fatigue - a Common Symptom in General Practice].
1Universitäres Zentrum für Hausarztmedizin beider Basel, Kantonsspital Baselland.
General practitioners should thoroughly assess patient-reported fatigue, considering individual explanations and daily impact. Excluding serious conditions like depression or sleep apnea is vital before exploring other causes.
Area of Science:
- General Practice
- Internal Medicine
- Symptomatology
Background:
- Fatigue is a prevalent symptom encountered in general practice.
- Understanding the patient's perspective on fatigue is crucial for effective diagnosis and management.
Purpose of the Study:
- To outline a systematic approach for general practitioners (GPs) managing patients presenting with fatigue.
- To emphasize the importance of a comprehensive evaluation, including patient-reported factors and potential underlying conditions.
Main Methods:
- In-depth patient history taking to understand the meaning, impact, and perceived causes of fatigue.
- Systematic exclusion of dangerous diseases like depression, addiction, and sleep apnea syndrome.
- Simultaneous exploration of main somatic and psychiatric causes of fatigue.
- Basic physical examination and laboratory tests to identify major disorders.
- Adoption of a primary biopsychosocial approach and fostering a strong physician-patient relationship.
Main Results:
- A structured approach allows for the identification of major disorders presenting with isolated fatigue.
- Initial assessment can be effectively supported by a simple physical exam and limited lab tests.
- Considering comorbidities is essential for accurate diagnosis and treatment planning.
Conclusions:
- GPs must elicit detailed information about fatigue, including patient perceptions and daily life impact.
- Excluding serious conditions and exploring common causes concurrently is recommended.
- A biopsychosocial framework and a strong physician-patient relationship are fundamental for managing fatigue effectively.
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