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Updated: Jan 19, 2026
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Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
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Cholesterol and Dementia: A Long and Complicated Relationship
Oliwia McFarlane1, Kornelia Kędziora-Kornatowska2
1Department of Public Health, Faculty of Health Sciences, Nicolaus Copernicus University Ludwik Rydygier Collegium Medicum, Bydgoszcz, Poland.
Current Aging Science
|September 19, 2019
Summary
Cholesterol
Area of Science:
- Neuroscience
- Biochemistry
- Gerontology
Background:
- Population aging increases demand for cognitive health strategies.
- Dementia, particularly Alzheimer's disease (AD), is a leading cause of elderly disability.
- Early diagnosis of cognitive decline and its risk factors is crucial for intervention.
Purpose of the Study:
- To examine the link between cholesterol (circulating and brain) and cognitive function.
- To explore cholesterol's potential role in the early diagnosis of cognitive disorders.
Main Methods:
- Comprehensive literature review on cholesterol and cognitive health.
Main Results:
- The causal link between high cholesterol and Alzheimer's disease (AD) or mild cognitive impairment (MCI) remains unconfirmed.
- Plasma 24(S)-hydroxycholesterol (24(S)-OHC) was proposed as an early marker for central nervous system (CNS) cholesterol imbalance, but studies show conflicting results.
- No reliable indicator for early cognitive deterioration has been identified despite extensive research.
Conclusions:
- Current understanding of cholesterol markers is insufficient for clinical use in identifying cognitive decline.
- Further research is needed to establish reliable cholesterol-based biomarkers for early detection of cognitive impairment.
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