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Skin Ageing: Pathophysiology and Current Market Treatment Approaches
Manupriya Chaudhary1, Azmi Khan1, Madhu Gupta1
1Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, Pushpvihar, Sector-3, M.B Road, New Delhi -110017, India.
Abstract:
Ageing is a natural phenomenon which is a fold, ridge and crease in the skin that occurs due to loss of body mass, poor hydration, disintegration of dermis and epidermis junction. The Skin ageing process involves many changes that occur due to the combination of both endogenous factors (gene mutation, cellular metabolism, and hormonal factor) and exogenous factors (U.V, pollutants, chemical, and toxins). In 1950, the number of older people were found to be almost 205 million across the globe. But this number almost got 4 times by the year 2012 and the number of older persons increased to a massive amount of 810 million. The ageing of the skin occurs due to various mechanisms like glycation, free radical, cell cycle, and cellular and molecular mechanism of skin ageing. In this review article, we have discussed the treatment, worldwide newer therapies and marketed formulation that are currently available for the reduction of skin ageing. The most promising and revolutionizing field of nanotechnology is mostly applied in the field of dermatology, cosmetics, and biomedical applications. Nanotechnology also plays a vital role in increasing the efficacy of the product.
Insights
Skin aging, characterized by wrinkles and loss of elasticity, results from intrinsic and extrinsic factors. This review explores current and emerging treatments, highlighting nanotechnology
Area of Science:
- Dermatology and Gerontology
- Cosmeceuticals and Biomedical Applications
Background:
- Skin aging is a natural process influenced by intrinsic factors like genetics and extrinsic factors such as UV exposure and pollutants.
- The global population of older individuals is rapidly increasing, driving demand for anti-aging solutions.
- Key mechanisms of skin aging include glycation, free radical damage, and cellular cycle alterations.
Purpose of the Study:
- To review current and novel therapeutic strategies for mitigating skin aging.
- To explore the role of nanotechnology in enhancing the efficacy of anti-aging treatments.
Main Methods:
- Comprehensive literature review of scientific articles and market formulations.
- Analysis of the application of nanotechnology in dermatology and cosmetics.
Main Results:
- Various treatments and marketed formulations for skin aging are available.
- Nanotechnology shows significant promise in improving the effectiveness of anti-aging products.
- Emerging therapies utilizing nanotechnology are revolutionizing dermatological applications.
Conclusions:
- Skin aging is a multifactorial process requiring diverse therapeutic approaches.
- Nanotechnology offers a promising avenue for developing more effective anti-aging interventions.
- Further research into nanotechnology-based solutions can significantly advance skin rejuvenation.
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