Related Experiment Video
Updated: Jan 19, 2026
DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
[Incidence and risk factors of extraintestinal manifestations in children with inflammatory bowel disease]
C Y Shan1, Q Q Zhang2, Y Xiao3
1Department of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China (Shan Chengyan is working on the Department of pediatrics, Yantai Yuhuangding Hospital, Yan tai 264000, China).
Insights
Children with inflammatory bowel disease (IBD) frequently develop extraintestinal manifestations (EIMs), particularly Crohn's disease (CD). Key risk factors for EIMs include CD, perianal disease, and younger age at diagnosis.
Area of Science:
- Pediatric Gastroenterology
- Inflammatory Bowel Disease Research
- Clinical Epidemiology
Background:
- Inflammatory Bowel Disease (IBD) encompasses Crohn's disease (CD) and ulcerative colitis (UC), affecting children with significant extraintestinal manifestations (EIMs).
- Understanding the incidence and risk factors of EIMs in pediatric IBD is crucial for timely diagnosis and management.
Purpose of the Study:
- To determine the incidence of EIMs in children diagnosed with IBD.
- To identify the specific risk factors associated with the development of EIMs in this pediatric population.
Main Methods:
- A retrospective analysis of 161 pediatric IBD patients (CD and UC) treated between 2012 and 2017.
- Logistic regression models were employed to analyze potential risk factors, including IBD phenotype, disease activity, and demographic data.
Main Results:
- Over half (54.7%) of pediatric IBD patients experienced EIMs, with immune-mediated conditions and growth retardation being most prevalent.
- Crohn's disease (CD), perianal disease, younger age at diagnosis (<6 years), and moderate-to-severe disease activity were identified as significant risk factors for EIMs.
Conclusions:
- Pediatric IBD patients exhibit a high incidence of EIMs, more frequently observed in CD than UC.
- Early identification of risk factors like CD, perianal disease, and disease severity is essential for proactive management of EIMs in children.
Abstract:
Objective: To investigate the incidence and risk factors of extraintestinal manifestations (EIMs) in children with inflammatory bowel disease (IBD). Methods: The clinical data of 161 children with IBD was collected from the electronic medical records in the Department of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine from January 2012 to December 2017. These patients were divided into Crohn's disease (CD) group and ulcerative colitis (UC) group, accounting for 82.0% (132 cases) and 18.0%(29 cases), respectively. The incidence of EIMs in each group was analyzed. The potential risk factors of EIMs including the IBD phenotype, gender, age, location of the CD lesion, disease activity of CD, and the presence of perianal lesion were analyzed with logistic regression model. Results: Eighty-eight patients (54.7%) had EIMs. The main EIMs were immune-mediated EIMs and growth retardation, accounting for 41.0% (66/161) and 24.2% (39/161), respectively. Aphthous ulcer (39/161, 23.0%) was the most common symptom among immune-mediated EIMs, followed by arthropathy (20/161, 12.4%) and skin lesions (19/161, 11.8%). Forty-three patients (26.7%) had EIMs before being diagnosed as IBD. Fifty-eight (65.9%) patients had only one EIM during the whole course of IBD. By logistic regression analysis, CD (OR=5.536, 95%CI:1.825-16.788) and perianal disease (OR=1.969, 95%CI:1.035-3.746) were the risk factors of immune-mediated EIMs. Meanwhile, CD (OR=11.319, 95%CI: 1.487-86.179), younger than six-year-old at diagnosis (OR=8.556, 95%CI: 3.109-23.545), moderate to severe activity of CD (OR=3.447, 95%CI: 1.196-9.934) and perianal disease (OR=3.361, 95%CI: 1.720-7.793) increased the risk of growth retardation. Conclusions: The children with IBD have a high incidence of EIMs, which were more common in CD than in UC. The risk factors of developing EIMs include CD, perianal diseases, younger than six-year-old at diagnosis and moderate to severe activity of CD.
Related Concept Videos
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:21Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
09:04DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
08:27Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
01:29Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...