Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nephrotoxic drugs.

S A Mendoza1

  • 1Department of Pediatrics, University of California, San Diego, La Jolla 92093.

Pediatric Nephrology (Berlin, Germany)
|October 1, 1988
PubMed
Summary
This summary is machine-generated.

This review examines common pediatric nephrotoxic drugs, highlighting synergistic effects and subtle early signs of kidney injury. Monitoring for early indicators is crucial for predicting severe drug-induced renal damage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estimated area-under-the-curve monitoring of Neoral in a stable pediatric renal transplant population: one-year experience.

Transplantation proceedings·1998
Same author

Treatment of the idiopathic nephrotic syndrome: regimens and outcomes in children and adults.

Journal of the American Society of Nephrology : JASN·1997
Same author

Steroid-resistant nephrotic focal segmental glomerulosclerosis: a treatable disease.

Pediatric nephrology (Berlin, Germany)·1996
Same author

Management of hypertension in the child with chronic renal disease.

The Journal of pediatrics·1996
Same author

Nitrogen mustard therapy of pediatric nephrotic syndrome.

Pediatric nephrology (Berlin, Germany)·1996
Same author

Management of the difficult nephrotic patient.

Pediatric clinics of North America·1995
Same journal

Correlation between urinary soluble CD163 and endocapillary proliferation and fibrinoid necrosis in IgA vasculitis with nephritis.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

SGLT2i, anti-endothelin A and double endothelin and angiotensin inhibitors: a new future for chronic kidney disease in children.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

The role of urinary trehalase levels in the early diagnosis of acute kidney injury in dehydrated children.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Neuron-specific enolase and brain-derived neurotrophic factor as developmental neurovascular markers in chronic kidney disease and kidney transplantation.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Chronic hyponatraemia with a reset osmostat: when abnormal is normal.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Clinical value of repeat kidney biopsy in pediatric IgA vasculitis nephritis.

Pediatric nephrology (Berlin, Germany)·2026
See all related articles

Area of Science:

  • Pediatric Nephrology
  • Clinical Pharmacology

Background:

  • Several common medications can cause kidney damage in children.
  • These drugs, including cyclosporine, aminoglycoside antibiotics, cisplatin, amphotericin B, beta-lactam antibiotics, and indomethacin, exhibit diverse mechanisms of nephrotoxicity.
  • Understanding these mechanisms is vital for managing pediatric renal health.

Purpose of the Study:

  • To review the nephrotoxic effects of frequently used drugs in children.
  • To identify common patterns and mechanisms of drug-induced renal injury.
  • To emphasize the importance of early detection of nephrotoxicity.

Main Methods:

  • Literature review of nephrotoxic agents commonly used in pediatric populations.
  • Analysis of mechanisms of renal injury caused by specific drugs.

Related Experiment Videos

  • Examination of factors influencing drug-induced nephrotoxicity, including drug interactions and pre-existing conditions.

    • Main Results:

    • Nephrotoxic agents causing tubular damage can exhibit synergistic toxic effects, especially when administered concurrently.
    • Concomitant use of nephrotoxic drugs or administration in patients with pre-existing renal disease can lead to severe tubular injury.
    • Serum drug levels may not reliably predict individual patient nephrotoxicity.
    • Early signs of renal injury, such as subtle electrolyte excretion changes, can precede overt acute renal failure and serve as important predictors.

    Conclusions:

    • Drug-induced nephrotoxicity in children is a significant concern.
    • Synergistic effects and pre-existing conditions exacerbate renal injury.
    • Subtle early indicators of renal damage are critical for timely intervention and prevention of severe outcomes.