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Related Concept Videos

Preparation of Janus Particles and Alternating Current Electrokinetic Measurements with a Rapidly Fabricated Indium Tin Oxide Electrode Array09:55

Preparation of Janus Particles and Alternating Current Electrokinetic Measurements with a Rapidly Fabricated Indium Tin Oxide Electrode Array

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In this article, a simple method to prepare partially or fully coated metallic particles and to perform AC electrokinetic property measurements with a rapidly fabricated indium tin oxide (ITO) electrode array is...
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Synthesis of Poly(N-isopropylacrylamide) Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability09:09

Synthesis of Poly(N-isopropylacrylamide) Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability

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We present a protocol to synthesize Janus microhydrogels composed entirely of the same base material, poly(N-isopropylacrylamide) (PNIPAAm), with a clearly compartmentalized structure base on the phase separation of a supersaturated NIPAAm monomer solution. The synthesized Janus microhydrogels show unique properties such as anisotropic thermo-responsiveness and organophilic/hydrophilic loading...
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Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer08:20

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The purpose of the method presented here is to show how microenvironment microarrays (MEMA) can be fabricated and used to interrogate the impact of thousands of simple combinatorial microenvironments on the phenotype of cultured...
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Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion07:14

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The goal of this protocol is to show the assembly of a biomimetic nanomatrix (NM) with Janus base nanotubes (JBNTs) and fibronectin (FN). When co-cultured with human mesenchymal stem cells (hMSCs), the NMs exhibit excellent bioactivity in encouraging hMSCs...
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Preparation of Hollow Polystyrene Particles and Microcapsules by Radical Polymerization of Janus Droplets Consisting of Hydrocarbon and Fluorocarbon Oils07:01

Preparation of Hollow Polystyrene Particles and Microcapsules by Radical Polymerization of Janus Droplets Consisting of Hydrocarbon and Fluorocarbon Oils

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A protocol for the fabrication of hollow polymer particles and microcapsules by radical polymerization using emulsions consisting of styrene, perfluoro-n-octane, and aqueous SDS (sodium dodecylsulfate) solution is...
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To rationally design efficient adjuvants, we developed poly-lactic-co-glycolic acid nanoparticle-stabilized Pickering emulsion (PNPE). The PNPE possessed unique softness and a hydrophobic interface for potent cellular contact and offered high-content antigen loading, improving the cellular affinity of the delivery system to antigen-presenting cells and inducing efficient internalization of antigens.
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Related Experiment Video

Updated: Jan 19, 2026

Preparation of Janus Particles and Alternating Current Electrokinetic Measurements with a Rapidly Fabricated Indium Tin Oxide Electrode Array
09:55

Preparation of Janus Particles and Alternating Current Electrokinetic Measurements with a Rapidly Fabricated Indium Tin Oxide Electrode Array

Published on: June 23, 2017

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Interrogating Cellular Functions with Designer Janus Particles.

Yi Yi1, Lucero Sanchez1, Yuan Gao1

  • 1Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.

Chemistry of Materials : a Publication of the American Chemical Society
|September 19, 2019
PubMed
Summary
This summary is machine-generated.

Janus particles, with their distinct surfaces, offer unique biological interactions. Understanding these interactions is key to developing advanced biomaterials for manipulating cellular functions.

More Related Videos

Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
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Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer
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Related Experiment Videos

Last Updated: Jan 19, 2026

Preparation of Janus Particles and Alternating Current Electrokinetic Measurements with a Rapidly Fabricated Indium Tin Oxide Electrode Array
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Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Colloidal Science

Background:

  • Janus particles possess two distinct surfaces, enabling applications beyond homogeneous particles.
  • Their unique properties are driving innovation in active colloidal metastructures and multimodal therapeutics.
  • Recent advancements focus on Janus particle applications within the biomedical field.

Purpose of the Study:

  • To explore how Janus particles with surface anisotropy interact with biological systems.
  • To understand how these interactions can be leveraged to manipulate biological responses.
  • To highlight recent studies using Janus particles as tools for cellular function manipulation and measurement.

Main Methods:

  • Review of recent studies employing Janus particles in biological contexts.
  • Analysis of how surface anisotropy influences particle-cell interactions.
  • Examination of techniques for visualizing and measuring particle dynamics in living systems.

Main Results:

  • Janus particles exhibit distinct biological interactions compared to uniform particles.
  • Surface anisotropy controls synthetic particle cell entry and immune cell activation.
  • Direct visualization and measurement of particle rotational dynamics in vivo are achievable.

Conclusions:

  • Understanding Janus particle-biological interactions is crucial for advancing biomaterials.
  • Harnessing these interactions holds significant potential for developing novel Janus structure-based biomaterials.
  • Janus particles represent a powerful toolset for manipulating and understanding cellular functions.