Photo- and dioxygen-enabled radical C(sp³)-N(sp²) cross-coupling between guanidines and perfluoroalkyl iodides

Source: Vy M. Dong and Faben Cruz, Department of Chemistry, University of California, Irvine, CA
This experiment will demonstrate the concept of a palladium-catalyzed cross coupling. The set-up of a typical Pd-catalyzed cross coupling reaction will be illustrated. Pd-catalyzed cross coupling reactions have had a profound effect on how synthetic chemists create molecules. These reactions have enabled chemists to construct bonds in new and more efficient ways. Such reactions have found widespread...

Photo-induced cross-linking of unmodified proteins (PICUP) allows characterization of oligomer size distribution in metastable protein mixtures. We demonstrate application of PICUP to three representative amyloidogenic peptides the 40- and 42-residue forms of amyloid β-protein, and calcitonin, and a control peptide growth-hormone releasing...

Radical-based biomimetic chemistry has been applied to building-up libraries necessary for biomarker...

The present protocol describes a detailed benchtop catalytic method that yields a unique borylated derivative of...

A protocol for the synthesis of alkyl-modified guanidines based on the use of the corresponding precursors is...

We describe a procedure used to collect in situ photo-rheology measurements of polymeric materials undergoing photo-responsive liquid-to-solid...