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Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice04:29

Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice

Presented here is a protocol to induce diffuse traumatic brain injury using a lateral fluid percussion device followed by the collection of the caecum content for gut microbiome...
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A Novel In Vitro Model of Blast Traumatic Brain Injury08:59

A Novel In Vitro Model of Blast Traumatic Brain Injury

This paper describes a novel model of primary blast traumatic brain injury. A compressed-air driven shock tube is used to expose in vitro mouse hippocampal slice cultures to a single shock wave. This is a simple and rapid protocol generating a reproducible brain tissue injury with a high throughput.
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Controlled Cortical Impact Model for Traumatic Brain Injury05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Traumatic brain injuries (TBIs) remain a serious health problem. Using the controlled cortical impact surgery model, research on the effects of TBI and possible treatment methods may be...
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A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury04:19

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury

Athletes absorb several hundred mild traumatic brain injuries (mTBI)/concussions every year; however, the consequence of these on the brain is poorly understood. Therefore, an animal model of single and repetitive mTBI that consistently replicates clinically relevant symptoms provides the means to advance the study of mTBI and...
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Impulsive Pressurization of Neuronal Cells for Traumatic Brain Injury Study09:24

Impulsive Pressurization of Neuronal Cells for Traumatic Brain Injury Study

A novel impulsive cell pressurization experiment has been developed using a Kolsky bar device to investigate the molecular/cellular mechanisms of blast-induced traumatic brain...
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Assessing Dominant-Submissive Behavior in Adult Rats Following Traumatic Brain Injury03:56

Assessing Dominant-Submissive Behavior in Adult Rats Following Traumatic Brain Injury

The present protocol describes a rat model of fluid percussion-induced traumatic brain injury followed by a series of behavioral tests to understand the development of dominant and submissive behavior. Using this model of traumatic brain injury in conjunction with specific behavioral tests enables the study of social impairments following brain injury.
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