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Updated: Jan 19, 2026
Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
Published on: August 19, 2021
Significant risk of occult cancer in complex non-atypical endometrial hyperplasia
Antonio Travaglino1, Antonio Raffone2, Gabriele Saccone3
1Anatomic Pathology Unit, Department of Advanced Biomedical Sciences, School of Medicine, University of Naples Federico II, Naples, Italy.
Background:
In the 2014 WHO classification of endometrial hyperplasia (EH), complex EH is lumped together with simple EH in the benign category of non-atypical EH.
Objective:
To assess the risk of coexistent cancer in complex EH and simple EH without atypia, through a systematic review and meta-analysis.
Methods:
Electronic databases were searched from their inception to January 2019 for relevant articles.
Results:
Twelve studies assessing a total of 804 non-atypical EH were included. The risk of coexistent cancer was significantly higher in complex EH (12.4%) than in simple EH (2%), with an OR of 6.03 (p = 0.0002).
Conclusion:
Even in the absence of cytologic atypia, complex EH is associated with a significant risk of coexistent cancer. Further studies are necessary to investigate the need for a revision in the WHO classification.
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