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Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
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Safety of Maternal Immunization Against Pertussis: A Systematic Review

Caroline D'Heilly1, Charlotte Switzer2, Denis Macina3

  • 1Sanofi Pasteur, Vaccines Epidemiology and Modeling, Lyon, France.

Infectious Diseases and Therapy
|September 19, 2019
PubMed

Insights

Maternal pertussis vaccination during pregnancy is safe for both mother and baby. This immunization strategy protects newborns from pertussis (whooping cough) through antibody transfer.

Area of Science:

  • Immunology
  • Maternal-Fetal Medicine
  • Public Health

Background:

  • Newborn infants are vulnerable to pertussis (whooping cough) despite widespread childhood vaccination.
  • Maternal pertussis vaccination during pregnancy aims to protect newborns via transplacental antibody transfer.

Purpose of the Study:

  • To review the safety and impact of maternal pertussis vaccination on pregnant women, fetuses, and newborns.

Main Methods:

  • A systematic review of 27 English language publications from January 1995 to December 2018.
  • Searched databases including PubMed/MEDLINE, EMBASE, Scopus, Cochrane, ProQuest, and Science Direct for safety data.

Main Results:

  • Maternal pertussis vaccination did not increase local or systemic reactions in pregnant women.
  • No safety concerns were identified with repeat or co-administration of tetanus-containing or influenza vaccines.
  • Pregnancy, birth, and neonatal outcomes were not adversely affected by maternal pertussis vaccination.

Conclusions:

  • Maternal pertussis vaccination during pregnancy is confirmed as safe.
  • This vaccination strategy offers a protective measure for newborns against pertussis.

Keywords:
Maternal immunizationPertussisPregnancyVaccineWhooping cough

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