Related Experiment Video
Updated: Jan 19, 2026

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
Published on: January 10, 2025
Sternal wound closure in the current era: the need of a tailored approach
Antonio Nenna1, Francesco Nappi2, Jennifer Dougal3
1Department of Cardiovascular Surgery, Università Campus Bio-Medico Di Roma, Via Alvaro del Portillo 200, 00128, Rome, Italy. a.nenna@unicampus.it.
Objective:
Median sternotomy remains the most common access to perform cardiac surgery procedures. However, the experience of the operating surgeon remains a crucial factor during sternal closure to avoid potential complications related to poor sternal healing, such as mediastinitis. Considering the lack of major randomized controlled trials and the heterogeneity of the current literature, this narrative review aims to summarize the different techniques and approaches to sternal closure with the aim to investigate their reflections into clinical outcomes and to inform the choice on the most effective closure method after median sternotomy.
Methods:
A literature search through PubMed, Embase, EBSCO, Cochrane database of systematic reviews, and Web of Science from its inception up to April 2019 using the following search keywords in various combinations: sternal, sternotomy, mediastinitis, deep sternal wound infection, cardiac surgery, closure.
Results:
Single wire fixation methods, at present, seems the most useful method to perform sternal closure in routine patients, although patients with a fragile sternum might benefit more from a figure-of-eight technique. In high-risk patients (e.g. chronic pulmonary disease, obesity, bilateral internal mammary artery harvesting, diabetes, off-midline sternotomy), rigid plate fixation is currently the most effective method, if available; alternatively, weave techniques could be used.
Conclusion:
The choice among the sternal closure techniques should be mainly inspired and tailored on the patient's characteristics, and correct judgement and experience play a pivotal role. A decisional algorithm has been proposed as an attempt to overcome the absence of specific guidelines and to guide the operative approach. This operative approach might be used also in non-cardiac procedure in which median sternotomy is required, such as in case of thoracic surgery.
More Related Videos
08:19Zebrafish Corneal Wound Healing: From Abrasion to Wound Closure Imaging Analysis
Published on: March 1, 2022
20:33A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
Published on: July 4, 2019
Related Concept Videos
07:56Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
08:19Zebrafish Corneal Wound Healing: From Abrasion to Wound Closure Imaging Analysis
20:33A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
07:16Swine Model of Biofilm Infection and Invisible Wounds
08:35Demonstration of the Rat Ischemic Skin Wound Model
05:39Murine Model of Wound Healing