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Related Concept Videos

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Related Experiment Video

Updated: Jan 19, 2026

Electromagnetic Navigation Transthoracic Nodule Localization for Minimally Invasive Thoracic Surgery
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Real-time electromagnetic navigation for breast-conserving surgery using NaviKnife technology: A matched case-control

Gabrielle Gauvin1,2, Caitlin T Yeo1, Tamas Ungi3

  • 1Department of Surgery, Queen's University, Kingston, ON, Canada.

The Breast Journal
|September 19, 2019
PubMed
Summary

NaviKnife, a new electromagnetic navigation system, proved feasible for nonpalpable breast cancer surgery. This surgical navigation technology allows for the removal of less breast tissue while maintaining accurate margin rates.

Keywords:
breast cancer surgerybreast-conserving therapyimage-guided surgerysurgical oncology

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Area of Science:

  • Surgical Oncology
  • Medical Devices
  • Breast Cancer Research

Background:

  • Breast-conserving surgery (BCS) is standard for breast cancer.
  • Accurate tumor removal is challenging for nonpalpable cancers, leading to high positive margin rates.
  • Existing methods lack precision for nonpalpable lesions.

Purpose of the Study:

  • To evaluate the feasibility of intraoperative electromagnetic (EM) navigation using NaviKnife for nonpalpable breast cancer.
  • To assess the impact of EM navigation on surgical outcomes, including margin status and tissue removal.
  • To compare the efficacy of NaviKnife-assisted BCS with traditional methods.

Main Methods:

  • A prospective study involving 40 patients with ultrasound-visible, nonpalpable breast cancer undergoing BCS.
  • Utilized the NaviKnife system for real-time EM tracking and surgical guidance.
  • Feasibility assessed via equipment performance, operative time, and surgeon feedback.
  • Compared outcomes (specimen volume, margin rates, reoperation) to a matched control group.

Main Results:

  • NaviKnife demonstrated feasibility with no equipment failures or sterility breaches.
  • Operative times were comparable between the NaviKnife and control groups (median 66 vs. 65 minutes).
  • NaviKnife excisions yielded significantly smaller specimen volumes (95.4 vs. 140.7 cm³; P=.01) without increasing positive margin rates (22.5% vs. 28.7%).
  • Re-excision rates for residual disease were lower in the NaviKnife group (14.3% vs. 50%).

Conclusions:

  • Real-time EM navigation with NaviKnife is a feasible and valuable tool for BCS of nonpalpable breast cancers.
  • NaviKnife facilitates the removal of less breast tissue while maintaining oncologic safety.
  • This technology holds potential to improve surgical precision and patient outcomes in breast cancer treatment.