Related Experiment Video
Updated: Jul 17, 2026

An Ex vivo Culture System to Study Thyroid Development
Published on: June 6, 2014
The Changes in Coagulation Test Results in Subjects with Varying Levels of Thyroid Stimulating Hormone
Background:
The aim is to investigate the changes in coagulation test results in subjects with varying serum levels of thyroid stimulating hormone.
Methods:
We performed a one-year retrospective analysis to retrieve combined results of activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (Fib), D-dimer, free thyroxine (fT4), tri-iodothyronine (fT3), and thyroid stimulating hormone (TSH) from inpatients who were referred by general practitioners for routine blood testing. Cumulative results were retrieved for 2,794 such inpatients.
Results:
Patients with a TSH level < 0.34 µIU/mL had higher PT values (10.43 ± 1.02 vs. 10.27 ± 0.91) and Fib values (3.00 ± 0.92 vs. 2.7 ± 0.56) compared with patients with 0.34 µIU/mL < TSH < 5.6 µIU/mL. Conversely, the PT values (10.01 ± 0.95 vs. 10.27 ± 0.91) were lower and APTT (33.70 ± 4.17 vs. 32.56 ± 4.12) values higher in patients with TSH > 5.6 µIU/mL compared to patients with 0.34 µIU/mL < TSH < 5.6 µIU/mL.
Conclusions:
There are changes in coagulation test results in subjects with varying levels of thyroid stimulating hormone.
Related Concept Videos
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Hyperthyroidism I: Introduction
Hyperthyroidism II: Pathophysiology
Graves Disease II: Pathophysiology
Hypothyroidism II: Pathophysiology

