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Nucleophilic Imines and Electrophilic o-Quinone Methides, a Three-Component Assembly of Assorted
Kazaf KC Chan1, Yuk Fai Wong1, Derek Yang1
1Department of Chemistry and Biochemistry , University of California, Santa Barbara , Santa Barbara , California 93106-9510 , United States.
Organic Letters
|September 19, 2019
Abstract:
A one-pot method for joining three separate components leading to an assortment of N-substituted 3,4-dihydro-2H-1,3-benzoxazines is described. The method involves the addition of a Grignard reagent to an o-OBoc salicylaldehyde in the presence of an imine. With a variety of components, 15 examples are presented, including the diastereoselective incorporation of chiral imines.