[Features of clinical picture of Herpes zoster in infants]
A S Shishov1, A K Shakaryan2, I H Belyaletdinova1
1Chumakov Federal Scientific Center for Research and Development of Immune-and-biological Products Russian Academy of Sciences, Moscow, Russia.
Insights
This study examines clinical features of Herpes zoster in infants. It highlights two rare cases, including intrauterine varicella-zoster virus infection and its potential for delayed neurological complications.
Area of Science:
- Pediatrics
- Virology
- Neurology
Background:
- Herpes zoster (HZ) is uncommon in infants, posing diagnostic challenges.
- Varicella-zoster virus (VZ) infection can have severe congenital or intrauterine manifestations.
- Understanding HZ in infants is crucial for early diagnosis and management of neurological sequelae.
Purpose of the Study:
- To investigate the clinical characteristics of Herpes zoster in infants.
- To describe rare cases of HZ presenting in early infancy.
- To analyze the genesis of motor disorders associated with HZ in this age group.
Main Methods:
- Clinical and neurological examinations were performed.
- Cerebrospinal fluid (CSF) analysis, including antibody levels via ELISA, was conducted.
- Magnetic resonance imaging (MRI) of the brain and spinal cord with contrast enhancement was utilized.
Main Results:
- Two rare cases of HZ in infants are reported.
- Case 1: A 3-month-old infant with rash and left hand monoparesis.
- Case 2: A 5-month-old infant with intrauterine VZ virus infection, presenting a 10-month latent phase before HZ manifestation.
Conclusions:
- HZ in infants can present with diverse neurological complications, such as monoparesis.
- Intrauterine VZ infection may lead to a significant latent period before HZ reactivation.
- Recognizing the potential for delayed motor disorders is essential in infants with a history of VZ exposure.
Objective:
To study clinical characteristics of Herpes zoster in infants.
Material And Methods:
Children underwent routine clinical/neurological, and laboratory/instrumental examinations (composition of cerebrospinal fluid (CSF), the level of specific antibodies in the blood and CSF assessed by ELISA, MRI of the brain and cervical spine and spinal cord with contrast enhancement).
Results And Conclusion:
Two rare cases of disease are reported: 1) a 3-month girl with polymorphic rash appeared on the skin and monoparesis of the left hand, 2) a 5-month girl due to infection with the varicella-zoster (VZ) virus occurred intrauterine. The data on the frequency and interpretation of the genesis of motor disorders in patients with different localization of rashes are presented. The authors draw attention to the latent phase (interval between the primary infection of the fetus and reactivation of VD-viral infection with a picture of HZ), which was 10 months.
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