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SBOLExplorer: Data Infrastructure and Data Mining for Genetic Design Repositories
Michael Zhang1, Zach Zundel1, Chris J Myers2
1School of Computing , University of Utah , Salt Lake City , Utah 84112 , United States.
SBOLExplorer enhances searching in the SynBioHub repository for synthetic biology designs. This system improves the discovery of genetic parts, circuits, and sequences encoded in the Standard Bio-Ontology Language (SBOL) format.
Area of Science:
- Synthetic Biology
- Bioinformatics
- Computational Biology
Background:
- SynBioHub is a repository for genetic designs using the Standard Bio-Ontology Language (SBOL) data format.
- Genetic constructs in SynBioHub are numerous and complex, hindering simple search and discovery.
- Existing search methods in SynBioHub are limited, often relying on basic pattern-matching.
Purpose of the Study:
- To develop an improved search system for the SynBioHub genetic design repository.
- To enhance the intuitive searching and discovery of genetic parts, circuits, and sequences.
- To address the limitations of current pattern-matching search implementations.
Main Methods:
- Introduction of SBOLExplorer, a novel search system for SynBioHub.
- Adaptation of World Wide Web data organization and search techniques for SBOL data.
- Integration of enhanced search methods into SynBioHub's data representation and retrieval.
Main Results:
- SBOLExplorer provides significantly improved search capabilities within SynBioHub.
- The system offers more intuitive discovery of genetic constructs.
- Enhanced search performance compared to previous pattern-matching methods.
Conclusions:
- SBOLExplorer represents a substantial advancement in navigating and utilizing the SynBioHub genetic design repository.
- The system's approach offers a scalable solution for managing and searching complex biological design data.
- Improved searchability facilitates synthetic biology research and development.
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