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Isolation and Transplantation of Different Aged Murine Thymic Grafts.
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Transplantation in infants less than 1 year of age

T E Nevins1

  • 1University of Minnesota Hospital, Minneapolis 55455.

Pediatric Nephrology (Berlin, Germany)
|April 1, 1987
PubMed

Insights

Infant renal transplants show promising long-term success, with most transplanted kidneys functioning well. Early transplantation in infants with end-stage renal failure is recommended due to the risks of chronic uremia and dialysis.

Area of Science:

  • Pediatric Nephrology
  • Transplantation Surgery
  • Infant Health

Background:

  • End-stage renal failure (ESRF) in infants presents significant challenges.
  • Chronic uremia and dialysis in infancy carry substantial risks.
  • Renal transplantation is a potential treatment option for infants with ESRF.

Purpose of the Study:

  • To evaluate the outcomes of renal transplantation in infants.
  • To assess the long-term graft survival and patient survival rates.
  • To determine the impact of infant renal transplantation on growth and development.

Main Methods:

  • Retrospective analysis of 13 infants who underwent renal transplantation between 1978 and 1985.
  • Assessment of graft function and patient survival.
  • Evaluation of growth and developmental milestones post-transplantation.

Main Results:

  • Nine out of 13 transplanted kidneys are still functioning.
  • Only two patients died during the study period.
  • Successfully transplanted infants demonstrated accelerated growth and development, often reaching normal age-related ranges.

Conclusions:

  • Infant renal transplantation can achieve comparable results to older pediatric groups.
  • Early consideration of renal transplantation is warranted for infants with ESRF.
  • Transplantation offers improved outcomes compared to chronic uremia or dialysis in infancy.

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