Related Experiment Video

Updated: Jan 19, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS

Published on: April 7, 2021

3.8K

Early fluid overload was associated with prolonged mechanical ventilation and more aggressive parameters in

Clarice Laroque Sinott Lopes1, Guilherme Unchalo Eckert2, Taís Sica da Rocha2

  • 1Pediatric Intensive Care Unit, Hospital da Criança Santo Antônio in Porto Alegre, Porto Alegre, Brazil.

Acta Paediatrica (Oslo, Norway : 1992)
|September 19, 2019
PubMed

Insights

Early fluid overload in critically ill children receiving mechanical ventilation (MV) is linked to increased ventilator settings and longer MV duration. However, it did not significantly impact mortality rates in this study.

Area of Science:

  • Pediatric Intensive Care
  • Critical Care Medicine
  • Nephrology

Background:

  • Fluid overload is a common complication in critically ill children.
  • Early recognition and management of fluid overload are crucial for patient outcomes.

Purpose of the Study:

  • To evaluate the impact of early fluid overload on outcomes in critically ill children receiving mechanical ventilation.
  • To examine the association between fluid overload and mechanical ventilation (MV), mortality, length of stay, and renal replacement therapy.

Main Methods:

  • Retrospective cohort study of pediatric intensive care unit patients requiring MV for over 24 hours.
  • Fluid overload percentage (FO%) calculated daily for the first 72 hours.
  • Statistical analysis to determine the effect of FO% on outcomes.

Main Results:

  • 186 MV episodes in 154 patients were analyzed; mortality rate was 12.4%.
  • A fluid overload of ≥10% was associated with higher peak inspiratory pressure, positive end-expiratory pressure, and increased need for renal replacement therapy.
  • Fluid overload ≥10% was independently associated with longer MV support duration.

Conclusions:

  • Early cumulative fluid overload of ≥10% in pediatric patients on MV is linked to more aggressive ventilatory parameters and prolonged MV duration.
  • Fluid overload did not demonstrate an independent association with mortality in this cohort.
Abstract

Keywords:
fluid maintenancefluid overloadmechanical ventilationoedemarenal replacement therapy

More Related Videos

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

558
Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit05:56

Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit

Published on: September 6, 2024

6.0K

Related Concept Videos

Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
647
Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
2.6K
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
470
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
801
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
3.4K
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.0K