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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Case Series: Minocycline-Associated Thyroiditis.

Kate Millington1, Alexandra Charrow2, Jessica Smith3

  • 1Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA, kate.millington@childrens.harvard.edu.

Hormone Research in Paediatrics
|September 19, 2019
PubMed
Summary
This summary is machine-generated.

Minocycline, an antibiotic used for acne, can cause transient non-autoimmune thyroiditis in adolescents. This thyroid dysfunction, characterized by abnormal thyroid-stimulating hormone (TSH) levels, resolves after minocycline discontinuation.

Keywords:
AcneMinocyclineTetracyclineThyroiditis

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Area of Science:

  • Endocrinology
  • Dermatology
  • Pharmacology

Background:

  • Minocycline, a tetracycline antibiotic, is known for benign thyroid pigmentation.
  • Reports linking minocycline to thyroid dysfunction are infrequent.
  • This study investigates minocycline's potential to cause thyroid dysfunction.

Observation:

  • Nine cases of non-autoimmune thyroiditis were identified in adolescents (14-17 years) using minocycline for acne.
  • Patients used minocycline for 6 months to 4 years.
  • Thyroiditis presented with symptoms or painless goiter, and thyrotoxicosis was treated in some cases.

Findings:

  • All cases of minocycline-induced thyroiditis were transient, resolving within 2-5 months.
  • One patient developed temporary hypothyroidism following thyroiditis.
  • Thyroid-stimulating hormone (TSH) levels were suppressed, with elevated thyroxine, and negative antithyroid antibodies.

Implications:

  • Minocycline should be considered in the differential diagnosis of thyroiditis in adolescents.
  • Patients prescribed minocycline should be informed about the risk of thyroid dysfunction.
  • Further research may clarify the mechanisms of minocycline-induced thyroid abnormalities.