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S100B Serum Level is Independent of Moderate Alcohol Intoxication

Laura Emine Stollhof1, Udo Obertacke2, David Eschmann2

  • 1Orthopädie und Unfallchirurgie, BG Unfallklinik Tübingen.

Zeitschrift Fur Orthopadie Und Unfallchirurgie
|September 19, 2019
PubMed
Abstract

Insights

Serum S100B levels in healthy volunteers were unaffected by moderate alcohol consumption. This suggests S100B can reliably indicate brain injury even in patients with low to moderate alcohol intoxication.

Area of Science:

  • Neurology
  • Toxicology
  • Biochemistry

Background:

  • Minor head injury (MHI) patients frequently have coexisting alcohol intoxication (up to 50%).
  • Alcohol can alter neurological symptoms, potentially leading to misdiagnosis or delayed treatment in MHI patients.
  • S100B is a proposed biomarker for MHI, but its reliability may be compromised by alcohol's influence on serum levels.

Purpose of the Study:

  • To investigate the relationship between blood ethyl alcohol concentration and serum S100B concentration.
  • To determine if alcohol intoxication affects S100B levels in a controlled experimental setting.
  • To assess the utility of S100B as a biomarker in intoxicated MHI patients.

Main Methods:

  • 58 healthy adult volunteers participated in the study.
  • Blood ethyl alcohol and serum S100B concentrations were measured before and after voluntary alcohol consumption.
  • Automated measuring systems (Cobas e411, Siemens Dimension Vista 1500) were used for sample analysis.

Main Results:

  • Post-consumption blood alcohol levels ranged from 0.23 to 1.92 g/l.
  • Serum S100B levels ranged from 0.021 to 0.115 µg/l (standard < 0.11 µg/l).
  • Pearson correlation (r=0.01181) indicated no significant relationship between alcohol and S100B concentrations; S100B levels were independent of alcohol intake at low to moderate levels.

Conclusions:

  • Moderate alcohol blood concentrations (around 1 g/l) do not significantly alter serum S100B concentrations in healthy individuals.
  • S100B remains a potentially valuable biomarker for detecting brain injury in patients with low to moderate alcohol intoxication.
  • The findings support the use of S100B for selecting MHI patients requiring further diagnostics, irrespective of mild to moderate alcohol influence.

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