Related Experiment Video

Updated: Jan 19, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

10.1K

Graphene oxide arms oncolytic measles virus for improved effectiveness of cancer therapy

Mao Xia1, Dongjun Luo2, Jie Dong3

  • 1Department of Laboratory Medicine, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, China.

Journal of Experimental & Clinical Cancer Research : CR
|September 20, 2019
PubMed
Abstract

Insights

Graphene oxide sheets (GOS) protected oncolytic viruses (OVs) from neutralizing antibodies, enhancing tumor targeting and improving cancer therapy outcomes in mice.

Area of Science:

  • Nanomedicine
  • Virology
  • Oncology

Background:

  • Replication-competent oncolytic viruses (OVs) are effective anticancer agents.
  • Preexisting neutralizing antibodies pose a challenge to OV efficacy.
  • Graphene oxide sheets (GOS) offer biocompatibility and targeted delivery potential.

Purpose of the Study:

  • To develop a strategy to overcome antibody neutralization of OVs.
  • To enhance the oncolytic efficacy of measles virus (MV-Edm) using GOS.
  • To evaluate the targeted delivery and antitumor effects of the modified OV.

Main Methods:

  • PEI-GOS-PEG-FA nanoparticles were synthesized.
  • PEI-GOS-PEG-FA was used to coat MV-Edm, forming GOS/MV-Edm.
  • In vitro and in vivo studies assessed infectivity, tumor targeting, viral replication, and antitumor effects.

Main Results:

  • GOS/MV-Edm demonstrated enhanced infectivity and oncolysis.
  • Elevated viral replication and improved antitumor effects were observed in tumor-bearing mice.
  • GOS/MV-Edm utilized folate receptors for cancer cell entry and was protected from antibody neutralization.

Conclusions:

  • GOS/MV-Edm significantly enhances viral replication and antitumor effects in solid tumors.
  • This GOS-based strategy offers a promising approach for improving OV cancer therapy.
  • The findings suggest a novel therapeutic strategy for cancer patients.
Keywords:
Delivery vectorGraphene oxide sheetsOncolytic measles virusTargeted cancer therapy

More Related Videos

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy08:51

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

9.5K
Production of High-Titer Recombinant Newcastle Disease Virus from Allantoic Fluid07:24

Production of High-Titer Recombinant Newcastle Disease Virus from Allantoic Fluid

Published on: May 25, 2022

4.3K

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.9K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.2K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
977
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
6.9K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.8K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K