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Updated: Jan 19, 2026

Ole Isacson: Development of New Therapies for Parkinson's Disease
Published on: April 29, 2007
Unusual cause of treatable Parkinsonism
Lou Wiblin1, Dipayan Mitra2, Naomi Warren2
1Neurosciences Department, Royal Victoria Infirmary, Newcastle upon Tyne, UK louise.wiblin@ncl.ac.uk.
Abstract:
A 78-year-old woman presented with features of bilateral, asymmetric Parkinsonism for 1 year, with prominent difficulties with continence, swallowing and apathy. Brain imaging showed evidence of chronic venous sinus thrombosis with dilated serpiginous vessels over the brain surface in keeping with a dural arteriovenous fistula, together with high T2 signal on MRI in the basal ganglia. Having responded only modestly to levodopa, she received 6 months of anticoagulation followed by embolisation of the dural arteriovenous fistula, with good response. Cerebral dural arteriovenous fistula is a rare, structural cause of atypical Parkinsonism.
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