Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.0K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.0K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

1.8K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.8K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

14.7K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
14.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NCCN Guidelines® Insights: Myeloproliferative Neoplasms, Version 2.2026.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

Infections Within 100 Days of Idecabtagene Vicleucel and Impact on Survival for Relapsed/Refractory Multiple Myeloma: A CIBMTR Analysis.

Transplantation and cellular therapy·2026
Same author

Comparison of Fludarabine Versus Bendamustine as a Lymphodepleting Chemotherapy Prior to CAR-T for Large Cell Lymphoma.

Transplantation and cellular therapy·2026
Same author

Evolution to complex karyotype disease in mono-allelic <i>TP53</i>-mutated myelodysplastic syndrome/acute myeloid leukemia: a cohort study.

Haematologica·2026
Same author

Incidence, Prevalence, and Survival Outcomes of Patients with Myeloproliferative Neoplasms in the United States: a SEER database analysis, years 2000-2021.

Research square·2026
Same author

A multicenter study of progression risk and outcomes in solitary bone plasmacytoma with and without marrow involvement.

Blood advances·2026

Related Experiment Video

Updated: Jan 19, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
11:14

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

9.6K

HHV-8-Associated Lymphoproliferative Disorders and Pathogenesis in an HIV-Positive Patient.

Carlo Guerrero1, Tania Jain2, Katalin Kelemen3

  • 1Department of Medicine, Houston Methodist Hospital, Houston, TX, USA.

Case Reports in Hematology
|September 20, 2019
PubMed
Summary

Human herpesvirus 8 (HHV-8) can cause Kaposi's sarcoma and multiple rare lymphoproliferative disorders (LPDs). This case highlights the sequential development of three distinct HHV-8-associated LPDs in one patient.

More Related Videos

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals
06:46

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

Published on: January 5, 2016

17.9K
Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

13.0K

Related Experiment Videos

Last Updated: Jan 19, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
11:14

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

9.6K
Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals
06:46

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

Published on: January 5, 2016

17.9K
Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

13.0K

Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Human herpesvirus 8 (HHV-8), or Kaposi's sarcoma-associated herpesvirus, is linked to Kaposi's sarcoma (KS) and lymphoproliferative disorders (LPDs).
  • HHV-8 drives lymphoproliferation through pathways like interleukin-6 receptor signaling.
  • The classification of HHV-8-associated LPDs is evolving, with the WHO recently adding HHV-8-positive germinotropic LPD (GLPD).

Observation:

  • A case study of an HIV-positive woman with a history of KS is presented.
  • The patient sequentially developed three rare HHV-8-associated LPDs: HHV-8-positive multicentric Castleman's disease (MCD), primary effusion lymphoma (PEL), and GLPD.
  • This represents the first reported instance of a patient presenting with this specific combination of LPDs.

Findings:

  • The case demonstrates the diverse clinical spectrum and sequential progression of HHV-8-associated diseases.
  • HHV-8 detection is clinically significant for diagnosing and managing these conditions.
  • Emerging variants suggest HHV-8-associated LPDs are a heterogeneous group requiring further classification refinement.

Implications:

  • This case underscores the importance of recognizing the expanding spectrum of HHV-8-associated LPDs.
  • Accurate diagnosis and management strategies are crucial for patients with multiple HHV-8-related conditions.
  • Further research is needed to fully understand and classify the diverse range of HHV-8-associated LPDs.