Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.2K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.2K
Reticular Dermis01:15

Reticular Dermis

4.5K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
4.5K
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

452
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
452
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

7.6K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.6K
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

4.0K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
4.0K
Skin Cancer01:30

Skin Cancer

5.7K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dermatologie (Heidelberg, Germany)·2026
Same author

Suicidal ideation in patients with skin conditions: A multicentre European study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

Interleukin-23p19 inhibitors for the treatment of moderate-to-severe psoriasis: an expert opinion of real-world evidence studies in Europe.

The Journal of dermatological treatment·2025
Same author

The Prurigo Control Test reflects the severity of itch and skin lesions in patients with chronic prurigo: Data from a real-world study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

Treatment of psoriasis with biologic and non-biologic targeted therapies in patients with latent tuberculosis infection or at risk for tuberculosis disease progression: Recommendations from a SPIN-FRT expert consensus.

Journal of the European Academy of Dermatology and Venereology : JEADV·2024
Same author

A cross-sectional study on gender differences in body dysmorphic concerns in patients with skin conditions in relation to sociodemographic, clinical and psychological variables.

Journal of the European Academy of Dermatology and Venereology : JEADV·2024

Related Experiment Video

Updated: Jan 19, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

834

[The skin and rheumatism].

S Ständer1, R J Ludwig2, D Thaçi3

  • 1Klinik für Dermatologie, Allergologie und Venerologie, UKSH Lübeck, Universität zu Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Deutschland. sascha.staender@uksh.de.

Der Orthopade
|September 20, 2019
PubMed
Summary

Skin inflammation can signal internal diseases, impacting joints and organs. Early diagnosis and interdisciplinary management are vital for conditions like psoriasis, atopic dermatitis, and systemic lupus erythematosus to prevent long-term damage.

Keywords:
Dermatitis, atopicInflammationPsoriasisScleroderma, localizedSystemic lupus erythematosus

More Related Videos

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

879
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

574

Related Experiment Videos

Last Updated: Jan 19, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

834
Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

879
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

574

Area of Science:

  • Dermatology and Rheumatology
  • Internal Medicine
  • Systemic Inflammatory Diseases

Background:

  • Chronic inflammatory skin diseases frequently coexist with systemic conditions like rheumatic and inflammatory bowel diseases.
  • Inflammation of the skin can serve as a visual indicator of internal or systemic inflammation.
  • Comorbidities such as metabolic, mental, and cardiovascular issues are common consequences of chronic inflammation.

Purpose of the Study:

  • To highlight the interconnectedness of skin diseases with systemic inflammatory conditions.
  • To emphasize the importance of distinguishing between localized and systemic diseases for appropriate treatment.
  • To underscore the necessity of interdisciplinary management for complex inflammatory disorders.

Main Methods:

  • Review of clinical presentations and associations between skin conditions and systemic diseases.
  • Clinical differentiation of localized scleroderma from systemic sclerosis.
  • Discussion of the impact of chronic inflammation on various organ systems.

Main Results:

  • Skin manifestations are common in chronic inflammatory disorders and can indicate systemic involvement.
  • Conditions like psoriasis and atopic dermatitis are linked to rheumatic and inflammatory bowel diseases.
  • Systemic diseases such as lupus erythematosus involve both skin and multiple organs.

Conclusions:

  • Interdisciplinary disease management is crucial for effectively treating patients with inflammatory skin and systemic conditions.
  • Proper diagnosis and treatment of localized scleroderma are essential to prevent long-term disability.
  • Recognizing skin as a marker for systemic inflammation aids in comprehensive patient care.