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Towards Identifying Genetic Biomarkers for Gastrointestinal Dysfunction in Autism
A E Shindler1,2, E L Hill-Yardin3, S Petrovski4
1Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Bundoora, VIC, 3086, Australia. aeshindler@students.latrobe.edu.au.
Journal of Autism and Developmental Disorders
|September 20, 2019
Summary
Genetic biomarkers for gastrointestinal dysfunction in autism were explored. Specific gene variants (SNPs) in Prolactin, IL-10, CD38, and OXTR show potential as indicators for GI issues in autism.
Area of Science:
- Genetics
- Neuroscience
- Gastroenterology
Background:
- Gastrointestinal (GI) dysfunction is common in individuals with autism spectrum disorder (ASD).
- The underlying genetic factors contributing to GI dysfunction in ASD remain largely unknown.
- Identifying genetic biomarkers could improve understanding and management of GI issues in autism.
Purpose of the Study:
- To investigate potential genetic biomarkers for gastrointestinal dysfunction symptoms in individuals with autism.
- To explore the genetic risk associated with GI dysfunction in the context of autism.
- To analyze single nucleotide polymorphisms (SNPs) related to GI dysfunction and autism.
Main Methods:
- Analysis of single nucleotide polymorphisms (SNPs) in 60 participants with autism and/or GI dysfunction.
- Statistical analysis to determine the significance of specific gene variants in relation to autism and GI dysfunction.
- Evaluation of Prolactin (PRL), Interleukin 10 (IL-10), Cluster of Differentiation 38 (CD38), and oxytocin receptor (OXTR) SNPs.
Main Results:
- Moderate statistical significance was observed for Prolactin (PRL) and Interleukin 10 (IL-10) SNPs in the autism group.
- Strong statistical significance was found for Cluster of Differentiation 38 (CD38) and oxytocin receptor (OXTR) SNPs in the GI dysfunction group.
- Specific SNPs (PRL, IL-10, CD38, OXTR) showed associations with GI dysfunction symptoms in the studied population.
Conclusions:
- PRL, IL-10, CD38, and OXTR gene variants are potential biomarkers for GI dysfunction in autism.
- Further research is warranted to validate these SNP expressions as reliable biomarkers.
- Understanding these genetic links may pave the way for targeted interventions for GI issues in autism.
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