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Cleavage of immunoglobulins by pathogenic yeasts of the genus Candida
1Department of Medical Microbiology, University of Göttingen, FRG.
Abstract:
The yeast-like fungi Candida albicans and Candida tropicalis are opportunistic pathogens which are distinguished from less virulent yeasts by the secretion of acid proteases. Candida proteases cleave various human immunoglobulins including IgA2 and secretory immunoglobulins. They cover a wider range of substrates than bacterial IgA-proteases, and possibly play a role in the pathogenesis of thrush and deep candidosis.
Insights
Certain Candida yeasts, like Candida albicans, secrete acid proteases that degrade human immunoglobulins. These proteases may contribute to candidiasis pathogenesis, impacting human health.
Area of Science:
- Mycology
- Immunology
- Pathogenesis
Background:
- Opportunistic fungal pathogens, Candida albicans and Candida tropicalis, are significant causes of human infections.
- These yeasts are distinguished by their production of acid proteases, unlike less virulent yeast species.
Purpose of the Study:
- To investigate the enzymatic activity of Candida acid proteases on human immunoglobulins.
- To explore the potential role of these proteases in the pathogenesis of candidiasis.
Main Methods:
- Analysis of secreted acid proteases from Candida albicans and Candida tropicalis.
- Incubation of proteases with various human immunoglobulin substrates, including IgA2 and secretory immunoglobulins.
Main Results:
- Candida proteases demonstrated cleavage activity against human immunoglobulins.
- The substrate range for Candida proteases was found to be broader than that of bacterial IgA-proteases.
Conclusions:
- Candida acid proteases possess the ability to degrade human immunoglobulins.
- These proteases may play a crucial role in the development of thrush and deep candidosis, contributing to disease progression.