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Enzyme specialization during the evolution of amino acid biosynthetic pathways
C Parsot1, I Saint-Girons, G N Cohen
1Département de Biochimie et Génétique Moléculaire, Institut Pasteur, Paris, France.
Abstract:
Amino acid sequence similarities detected between enzymes involved in methionine and cysteine biosynthesis, and between enzymes involved in the threonine, isoleucine and tryptophan biosynthetic pathways allow an experimental investigation of the mechanisms whereby metabolic pathways have evolved.