Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antigenic variation in parasitic protozoa.

G Langsley1, C Roth

  • 1Department of Immunology, Pasteur Institute, Paris, France.

Microbiological Sciences
|September 1, 1987
PubMed
Summary

Antigenic variation in malaria and African sleeping sickness parasites presents challenges for vaccine development. Understanding the molecular mechanisms of new variant antigen generation is crucial for effective control strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Criteria for the use of plasmapheresesis in optic neuritis: A practice review from French expert centers.

Revue neurologique·2025
Same author

Performance comparison of a previously validated microhaplotype panel and a forensic STR panel for DNA mixture analysis.

Forensic science international. Genetics·2024
Same author

Lean mass sparing in resistance-trained athletes during caloric restriction: the role of resistance training volume.

European journal of applied physiology·2022
Same author

Whole-body [<sup>18</sup>F]-FDG-PET/MRI for staging of pediatric non-Hodgkin lymphoma: first results from a single-center evaluation.

EJNMMI research·2021
Same author

A Theoretical Investigation of the Configurations (3<i>d</i> + 4<i>s</i>)<sup>4</sup>4<i>p</i> in Neutral Vanadium (V i).

Journal of research of the National Bureau of Standards. Section A, Physics and chemistry·2020
Same author

A Theoretical Investigation of the Configurations (3<i>d</i> + 4<i>s</i>)<sup>5</sup> 4<i>p</i> in Neutral Chromium (Cr I).

Journal of research of the National Bureau of Standards. Section A, Physics and chemistry·2020

Area of Science:

  • Parasitology
  • Immunology
  • Molecular Biology

Background:

  • Protozoan parasites causing malaria and African sleeping sickness exhibit antigenic variation.
  • This variation allows parasites to evade host immune responses, leading to persistent infections.

Purpose of the Study:

  • To examine antigenic variation in malaria and African sleeping sickness parasites.
  • To review molecular mechanisms generating new variant antigens.
  • To discuss challenges in vaccine development due to antigenic variation.

Main Methods:

  • Literature review of studies on protozoan parasite antigenic variation.
  • Analysis of molecular mechanisms underlying variant antigen expression.
  • Discussion of vaccine development implications.

Main Results:

  • Antigenic variation is a key survival strategy for these parasites.
  • Specific molecular mechanisms contribute to the generation of diverse parasite antigens.
  • The continuous emergence of new variants complicates the design of effective vaccines.

Conclusions:

  • Antigenic variation poses a significant hurdle for developing vaccines against malaria and African sleeping sickness.
  • Further research into parasite immune evasion mechanisms is needed to inform vaccine design.

Related Experiment Videos