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Related Concept Videos

Prochirality02:05

Prochirality

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The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
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SN1 Reaction: Stereochemistry02:15

SN1 Reaction: Stereochemistry

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This lesson provides an in-depth discussion of the stereochemical outcomes in an SN1 reaction.
In the first step of an SN1 reaction, the bond between the electrophilic carbon and the leaving group ionizes to generate the carbocation intermediate. The second step of the mechanism is the nucleophilic attack.
In the formed carbocation, the positively charged carbon is sp2 hybridized with a trigonal planar geometry. As all the three substituents lie on the same plane, a plane of symmetry for the...
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SN2 Reaction: Stereochemistry02:23

SN2 Reaction: Stereochemistry

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In an SN2 reaction, the nucleophilic attack on the substrate and departure of the leaving group occurs simultaneously through a transition state. As the nucleophile approaches the substrate from the back-side, the configuration of the substrate carbon changes from tetrahedral to trigonal bipyramidal and then back to tetrahedral, leading to an inversion in the configuration of the product.
If the substrate is an achiral molecule at the α-carbon, the inversion of configuration is not...
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Radical Halogenation: Stereochemistry01:33

Radical Halogenation: Stereochemistry

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Stereochemistry is the study of the different spatial arrangements of atoms in a given molecule. The stereochemistry of radical halogenations can be understood from three different situations:
Halogenation to form a new chiral center:
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Chirality02:25

Chirality

29.1K
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
29.1K
Regioselectivity of Electrophilic Additions to Alkenes: Markovnikov's Rule02:17

Regioselectivity of Electrophilic Additions to Alkenes: Markovnikov's Rule

16.5K
If a set of reactants can yield multiple constitutional isomers, but one of the isomers is obtained as the major product, the reaction is said to be regioselective. In such reactions, bond formation or breaking is favored at one reaction site over others.
The hydrohalogenation of an unsymmetrical alkene can yield two haloalkane products, depending on which vinylic carbon takes up the halogen. However, one product usually predominates, where hydrogen adds to the vinylic carbon bearing the...
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Related Experiment Video

Updated: Jan 19, 2026

Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators
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Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators

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Chirality Transfer in Galvanic Replacement Reactions.

Junjun Liu1,2, Ziyue Ni1, Proloy Nandi3

  • 1Department of Physics , Hong Kong Baptist University (HKBU) , Kowloon Tong, Kowloon , Hong Kong SAR , China.

Nano Letters
|September 20, 2019
PubMed
Summary
This summary is machine-generated.

This study demonstrates a new method for transferring chirality from sacrificial template nanoparticles to create novel binary alloy chiral nanoparticles (CNPs). This versatile technique enables the development of advanced materials for various chirality-dependent applications.

Keywords:
Galvanic replacement reactionbinary alloychiral nanoparticleschirality transferglancing angle deposition

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemical Engineering

Background:

  • Chirality transfer in nanoparticles is crucial for applications in catalysis and sensing.
  • Existing methods for creating chiral nanoparticles are limited in scope and versatility.

Purpose of the Study:

  • To develop a general method for synthesizing binary alloy chiral nanoparticles (CNPs) with engineerable composition.
  • To investigate the transfer of structural chirality via galvanic replacement reactions (GRR).

Main Methods:

  • Utilizing metallic CNPs with intrinsic structural chirality as sacrificial templates (STs).
  • Employing galvanic replacement reactions (GRR) to form binary alloy CNPs.
  • Characterizing the morphology and composition of the resulting CNPs.

Main Results:

  • Successfully formed Cu-Ag CNPs with solid morphology.
  • Generated mesoporous CNPs composed of Ag-Au, Ag-Pt, and Ag-Pd alloys.
  • Demonstrated a general phenomenon of GRR-mediated chirality transfer.

Conclusions:

  • Introduced structural chirality as a key component in GRR.
  • Provided fundamental insights into the GRR principle.
  • Devised a versatile method for generating mesoporous alloy CNPs for advanced applications.