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Updated: Jan 19, 2026

Hyperpolarized Xenon for NMR and MRI Applications
Published on: September 6, 2012
Multiple Quantum Coherences Hyperpolarized at Ultra-Low Fields
Kai Buckenmaier1, Klaus Scheffler1,2, Markus Plaumann3
1High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Max-Planck-Ring 11, 72076, Tübingen, Germany.
Abstract:
The development of hyperpolarization technologies enabled several yet exotic NMR applications at low and ultra-low fields (ULF), where without hyperpolarization even the detection of a signal from analytes is a challenge. Herein, we present a method for the simultaneous excitation and observation of homo- and heteronuclear multiple quantum coherences (from zero up to the third-order), which give an additional degree of freedom for ULF NMR experiments, where the chemical shift variation is negligible. The approach is based on heteronuclear correlated spectroscopy (COSY); its combination with a phase-cycling scheme allows the selective observation of multiple quantum coherences of different orders. The nonequilibrium spin state and multiple spin orders are generated by signal amplification by reversible exchange (SABRE) and detected at ULF with a superconducting quantum interference device (SQUID)-based NMR system.
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