The relationship between anogenital distance and lifelong premature ejaculation

Area of Science:

• Reproductive Health
• Andrology
• Developmental Biology

Background:

• Anogenital distance is recognized as a potential indicator of intrauterine androgen exposure.
• Previous research has linked various diseases to anogenital distance measurements.

Purpose of the Study:

• To investigate the relationship between lifelong premature ejaculation and anogenital distance.
• To explore anogenital distance as a potential biomarker in andrology.

Main Methods:

• A comparative study involving 140 participants: 70 with lifelong premature ejaculation and 70 controls.
• Evaluation of ejaculatory function using the Premature Ejaculation Diagnostic Tool and intravaginal ejaculatory latency time.
• Measurement of two anogenital distance variants: anus to posterior scrotum and anus to penile base.

Main Results:

• A statistically significant difference in anogenital distance (anus to posterior scrotum) was found between the premature ejaculation group and the control group (p=0.01).
• A positive correlation was observed between anogenital distance (anus to posterior scrotum) and Premature Ejaculation Diagnostic Tool scores (r=0.199, p=0.019).
• A negative correlation was found between anogenital distance (anus to posterior scrotum) and intravaginal ejaculatory latency time (r=-0.185, p=0.028).

Conclusions:

• Findings suggest a potential association between a longer anogenital distance (anus to posterior scrotum) and an increased likelihood of lifelong premature ejaculation.
• The study highlights the need for further investigation to validate these findings and understand the underlying mechanisms.