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Lower Limb Arterial Calcification and Acute Thrombosis Risk in Patients with Peripheral Artery Disease

Zhihui Chang1, Hankun Yan1, Yanhua Zhen1

  • 1Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.

Annals of Vascular Surgery
|September 20, 2019
PubMed

Insights

Lower limb arterial calcification (LLAC) is inversely associated with acute thrombosis in peripheral artery disease (PAD) patients. Higher LLAC scores indicate a lower risk of acute thrombosis in symptomatic PAD.

Area of Science:

  • Vascular Medicine
  • Radiology
  • Thrombosis Research

Background:

  • Calcification in coronary arteries is linked to thrombosis.
  • The relationship between lower extremity arterial calcification (LLAC) and acute thrombosis is not well-established.
  • This study investigates the correlation between LLAC and acute thrombosis in symptomatic peripheral artery disease (PAD).

Purpose of the Study:

  • To determine if lower limb arterial calcification (LLAC) is correlated with acute thrombosis in patients with symptomatic peripheral artery disease (PAD).

Main Methods:

  • Retrospective review of 201 patients with symptomatic PAD undergoing CT angiography.
  • Assessment of patient characteristics, cardiovascular risk factors, and LLAC scores from noncontrast CT scans.
  • Univariate and multivariate logistic regression analysis to identify factors associated with acute thrombosis.

Main Results:

  • 24 patients had acute thrombosis; 177 did not.
  • Acute thrombosis patients were younger and had less diabetes but more advanced ischemia and higher amputation rates.
  • Multivariable analysis revealed an independent inverse association between LLAC score and acute thrombosis (OR 0.60).

Conclusions:

  • The lower limb arterial calcification (LLAC) score is independently and inversely associated with acute thrombosis in patients with PAD.
  • This finding suggests a potential protective role of LLAC against acute thrombosis in this population.
Abstract

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