Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

501
Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
501
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

1.4K
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
1.4K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

365
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
365
Narcolepsy01:07

Narcolepsy

510
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
510
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

478
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
478
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

2.7K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psychological interventions for migraine.

Nature reviews. Neurology·2026
Same author

Gender inequalities and the burden of anorexia and bulimia in Europe, 1990-2023: findings from the global burden of disease study 2023.

European journal of public health·2026
Same author

Effectiveness and Lessons Learned From an Occupational E-Mental Health Intervention for Enhancing Workplace Mental Health: The EMPOWER Cluster Randomized Controlled Trial.

Interactive journal of medical research·2026
Same author

Migraine, headache disorders, and brain health: aligning advocacy with the UN Sustainable Development Goals.

The journal of headache and pain·2026
Same author

OnabotulinumToxinA Reduces Pharmacological Burden in Chronic Migraine Patients: A Two-Center Prospective Cohort Study.

Toxins·2026
Same author

An AI-based nomogram (the CGRP score) for the prediction of response to modern migraine therapies: an independent assessment and some considerations on the application of AI tools in clinical setting.

The journal of headache and pain·2026
Same journal

Combined Olfactory Testing and Substantia Nigra Hyperechogenicity for Diagnostic Differentiation of Parkinson's Disease.

European neurology·2026
Same journal

The Role of Stroke Severity in the Association between Hypoperfusion Intensity Ratio and Futile Reperfusion after Endovascular Treatment.

European neurology·2026
Same journal

The Parkinsonism of Salvador Dalí.

European neurology·2026
Same journal

Disorders of Arousal and Sleep-Related Hypermotor Epilepsy in Adults: A Challenging but Necessary and Critical Distinctive Diagnosis.

European neurology·2026
Same journal

Sex-Specific Phenotypic Characteristics in Obstructive Sleep Apnea: A Comprehensive Analysis of Anthropometric, Hematological, and Metabolic Profiles Stratified by Disease Severity.

European neurology·2026
Same journal

Historical and Clinical Analysis of a Case of Progressive Muscular Atrophy (1853-1871).

European neurology·2026
See all related articles

Related Experiment Video

Updated: Jan 19, 2026

Author Spotlight: Insights into Remotely Supervised Neuromodulation Procedure for Phantom Limb Pain
06:13

Author Spotlight: Insights into Remotely Supervised Neuromodulation Procedure for Phantom Limb Pain

Published on: March 1, 2024

1.8K

Phantom Restless Legs Syndrome.

Alberto Raggi1, Raffaele Ferri2

  • 1Unit of Neurology, G.B. Morgagni - L. Pierantoni Hospital, Forlì, Italy, albertoraggi@libero.it.

European Neurology
|September 20, 2019
PubMed
Summary
This summary is machine-generated.

Phantom limb sensations can include painful restless legs syndrome (RLS). Dopamine agonists effectively treated phantom RLS (pRLS), suggesting insights into phantom pain and central nervous system body image representation.

Keywords:
Dopamine receptor agonistPainPhantom limbRestless legs syndromeReview

More Related Videos

Quantifying Arms and Legs Contributions during Repetitive Electrically-Assisted Sit-To-Stand Exercise in Paraplegics: A Pilot Study
08:40

Quantifying Arms and Legs Contributions during Repetitive Electrically-Assisted Sit-To-Stand Exercise in Paraplegics: A Pilot Study

Published on: November 11, 2022

1.4K
Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain
11:29

Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain

Published on: April 20, 2019

10.3K

Related Experiment Videos

Last Updated: Jan 19, 2026

Author Spotlight: Insights into Remotely Supervised Neuromodulation Procedure for Phantom Limb Pain
06:13

Author Spotlight: Insights into Remotely Supervised Neuromodulation Procedure for Phantom Limb Pain

Published on: March 1, 2024

1.8K
Quantifying Arms and Legs Contributions during Repetitive Electrically-Assisted Sit-To-Stand Exercise in Paraplegics: A Pilot Study
08:40

Quantifying Arms and Legs Contributions during Repetitive Electrically-Assisted Sit-To-Stand Exercise in Paraplegics: A Pilot Study

Published on: November 11, 2022

1.4K
Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain
11:29

Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain

Published on: April 20, 2019

10.3K

Area of Science:

  • Neuroscience
  • Pain Management
  • Clinical Neurology

Background:

  • Amputees frequently experience phantom limb sensations, which can include pain.
  • Restless Legs Syndrome (RLS) can occur in amputees or persist post-amputation.

Purpose of the Study:

  • To review clinical elements for diagnosing and treating phantom RLS (pRLS).
  • To explore the implications of pRLS for understanding central nervous system body image and phantom pain.

Main Methods:

  • Literature review of papers on phantom RLS (pRLS).

Main Results:

  • Dopamine receptor agonists demonstrated significant reduction in RLS symptoms in all reported cases.
  • pRLS supports the concept of a persistent internal body image in the central nervous system.

Conclusions:

  • pRLS may offer insights into phantom pain mechanisms.
  • Further research into pRLS could lead to novel treatment strategies for phantom sensations.