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Updated: Jan 19, 2026

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CNDP2 Acts as an Activator for Human Ovarian Cancer Growth and Metastasis via the PI3K/AKT Pathway

Li Q Zhang1, Hua Q Yang1, Su Q Yang1

  • 1Department of Gynecology, Taizhou Central Hospital, Taizhou, China.

Technology in Cancer Research & Treatment
|September 21, 2019
PubMed
Abstract

Insights

Cytosolic nonspecific dipeptidase 2 promotes ovarian cancer growth and metastasis by activating the PI3K/AKT pathway. This enzyme is highly expressed in ovarian tumors and drives cancer progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • The mechanisms of ovarian cancer tumorigenesis and metastasis remain incompletely understood.
  • Identifying key molecular players is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the role of cytosolic nonspecific dipeptidase 2 in ovarian cancer.
  • To elucidate the molecular mechanisms underlying its involvement in tumorigenesis and metastasis.

Main Methods:

  • Assessed cytosolic nonspecific dipeptidase 2 expression in ovarian cancer tissues and cell lines.
  • Utilized MTT, clone formation, and Transwell assays to evaluate cell proliferation and migration.
  • Conducted *in vivo* xenograft experiments and Western blotting to analyze PI3K/AKT pathway activation.

Main Results:

  • Cytosolic nonspecific dipeptidase 2 is highly expressed in ovarian cancer tissues and correlates with metastasis.
  • Overexpression of cytosolic nonspecific dipeptidase 2 promotes ovarian cancer cell proliferation, migration, and invasion.
  • Inhibition of cytosolic nonspecific dipeptidase 2 reduces tumor development and progression *in vivo*.
  • Elevated cytosolic nonspecific dipeptidase 2 expression increases phosphorylated PI3K and AKT levels.

Conclusions:

  • Cytosolic nonspecific dipeptidase 2 significantly promotes ovarian cancer occurrence and development.
  • The PI3K/AKT signaling pathway is a key mediator of cytosolic nonspecific dipeptidase 2's oncogenic functions in ovarian cancer.
Keywords:
CNDP2growthmetastasisovarian cancer

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