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Related Concept Videos

Secondary Lymphoid Organs01:15

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
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Second primary malignancy in diffuse large B-cell lymphoma patients: A SEER database analysis.

Shiyu Jiang1, Hongnan Zhen2, Hongxin Jiang3

  • 1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Current Problems in Cancer
|September 21, 2019
PubMed
Summary
This summary is machine-generated.

Patients with diffuse large B-cell lymphoma (DLBCL) face an increased risk of developing second primary malignancies (SPM). Awareness of these elevated risks is crucial for DLBCL survivors and their healthcare providers.

Keywords:
Diffuse large B-cell lymphomaRiskSEER ProgramSecond primary malignancy

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Area of Science:

  • Hematology
  • Oncology
  • Cancer Epidemiology

Background:

  • Previous studies indicate elevated risks of second primary malignancies (SPM) following Hodgkin lymphoma and non-Hodgkin lymphoma.
  • Research quantifying SPM risks specifically in diffuse large B-cell lymphoma (DLBCL) patients is limited.

Purpose of the Study:

  • To investigate and quantify the risks of developing SPM in patients diagnosed with DLBCL.
  • To identify specific cancer types and anatomical sites with increased SPM risk in DLBCL survivors.

Main Methods:

  • Utilized the US population-based SEER 9 Regs Custom Data (Nov 2016 Sub) for analysis.
  • Calculated standardized incidence ratios (SIR) and absolute excess risk (AER) with 95% confidence intervals (CIs) to assess SPM risks.

Main Results:

  • Identified 3751 SPM cases among DLBCL patients, yielding a SIR of 1.19 (95% CI: 1.16-1.23).
  • Significantly higher risks observed for oral cavity/pharynx, hepatobiliary, head/neck, thorax, bone/soft tissue, skin, breast, urinary tract, and endocrine system malignancies.
  • Elevated risks for leukemia, myeloma, lymphoma, Kaposi sarcoma, and specific radiation-associated cancers (colon/rectum/anus, bone/joint, melanoma) noted, particularly in younger (<45 years) and radiation-treated patients.

Conclusions:

  • DLBCL survivors exhibit a significantly increased risk of developing subsequent primary malignancies.
  • Enhanced surveillance and awareness are essential for DLBCL survivors and their physicians to manage these elevated risks effectively.