Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Surface Membrane Barriers01:18

Surface Membrane Barriers

2.6K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
2.6K
Epithelial Tissues and Their Functions01:23

Epithelial Tissues and Their Functions

38.2K
Epithelial tissues are large sheets of cells covering all of the surfaces of the body. These surfaces can be internal or external, for example, skin, airways, the digestive tract, the urinary system, and the reproductive system. Hollow organs and body cavities that do not connect to the body's exterior, including blood vessels and serous membranes, are lined by epithelial tissue known as the endothelium.
Epithelial tissues provide the body's first line of protection from physical,...
38.2K
Hand hygiene01:23

Hand hygiene

5.6K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
5.6K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

7.5K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
7.5K
Adaptations that Reduce Water Loss01:57

Adaptations that Reduce Water Loss

27.9K
Though evaporation from plant leaves drives transpiration, it also results in loss of water. Because water is critical for photosynthetic reactions and other cellular processes, evolutionary pressures on plants in different environments have driven the acquisition of adaptations that reduce water loss.
27.9K
Classification of Epithelial Tissues: Glandular Epithelium01:20

Classification of Epithelial Tissues: Glandular Epithelium

11.7K
The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
11.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advancing mechanobiology from single molecules to complex cellular systems.

Nature nanotechnology·2026
Same author

Mechanically Programmable DNA Hydrogel Microparticles for 3D Cellular Systems.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Fibronectin matrix remodelling modulates the active nematic dynamics of cancer-associated fibroblasts.

Nature materials·2026
Same author

Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton.

Nature materials·2026
Same author

Guidance of cellular nematic elastomers into shape-programmable living surfaces.

Science (New York, N.Y.)·2026
Same author

Cardiac fibroblast anisotropy is determined by YAP-dependent cellular contractility and ECM production.

Biomaterials·2026

Related Experiment Video

Updated: Jan 19, 2026

Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica
07:47

Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica

Published on: February 10, 2023

2.1K

Active wetting of epithelial tissues.

Carlos Pérez-González1,2, Ricard Alert3,4, Carles Blanch-Mercader5,6

  • 1Institute for Bioengineering of Catalonia, The Barcelona Institute for Science and Technology (BIST), Barcelona 08028, Spain.

Nature Physics
|September 21, 2019
PubMed
Summary

Tissue morphology changes, like those in development and cancer, are explained by active wetting transitions. This new model reveals a critical tissue size for these transitions, driven by cellular forces.

More Related Videos

Microscopy Based Methods for the Assessment of Epithelial Cell Migration During In Vitro Wound Healing
08:34

Microscopy Based Methods for the Assessment of Epithelial Cell Migration During In Vitro Wound Healing

Published on: January 2, 2018

9.9K
Scalable Stamp Printing and Fabrication of Hemiwicking Surfaces
06:16

Scalable Stamp Printing and Fabrication of Hemiwicking Surfaces

Published on: December 18, 2018

7.6K

Related Experiment Videos

Last Updated: Jan 19, 2026

Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica
07:47

Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica

Published on: February 10, 2023

2.1K
Microscopy Based Methods for the Assessment of Epithelial Cell Migration During In Vitro Wound Healing
08:34

Microscopy Based Methods for the Assessment of Epithelial Cell Migration During In Vitro Wound Healing

Published on: January 2, 2018

9.9K
Scalable Stamp Printing and Fabrication of Hemiwicking Surfaces
06:16

Scalable Stamp Printing and Fabrication of Hemiwicking Surfaces

Published on: December 18, 2018

7.6K

Area of Science:

  • Biophysics
  • Cell Biology
  • Morphogenesis

Background:

  • Tissue morphology changes are crucial in development, regeneration, and cancer.
  • Previous analogies to fluid wetting lack a mechanistic understanding of active cellular forces.

Purpose of the Study:

  • To investigate the transition between 2D epithelial monolayers and 3D spheroidal aggregates as an active wetting transition.
  • To theoretically account for and measure active cellular forces driving tissue wetting.

Main Methods:

  • Developed an active polar fluid model.
  • Measured physical forces related to tissue size, contractility, adhesion, and substrate stiffness.
  • Combined theoretical modeling with experimental force measurements.

Main Results:

  • The 2D to 3D tissue transition is an active wetting transition, distinct from passive wetting.
  • A critical tissue size for wetting transitions emerges from competing traction and contractile stresses.
  • Active shape fluctuations are amplified during tissue dewetting.

Conclusions:

  • Tissue spreading is a key example of active wetting.
  • This active wetting framework explains morphological transitions in tissue morphogenesis and tumor progression.
  • Introduced a novel physical scenario for understanding dynamic tissue morphology.