Related Experiment Video
Updated: Jan 19, 2026
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Periodontitis and cerebrovascular disease: a new novel in medicine
V Campanella1, L Oberti2, F Gabrione2
1Department of Clinical and Translational Medicine, Tor Vergata University of Rome, Rome, Italy.
Insights
This review found a link between periodontal disease and stroke. Individuals with stroke show a higher prevalence of periodontitis, suggesting a connection between oral health and cerebrovascular events.
Area of Science:
- Oral Health and Neurology
- Public Health
- Epidemiology
Background:
- Periodontal disease is a common oral infection.
- Stroke is a leading cause of death and disability worldwide.
- The potential association between periodontal disease and stroke requires investigation.
Purpose of the Study:
- To review and synthesize existing literature on the relationship between periodontal disease and stroke.
- To determine if a statistically significant association exists between these two conditions.
Main Methods:
- A comprehensive literature search was conducted across PubMed, Scopus, and Embase databases.
- Studies published in English within the last ten years, focusing on human subjects, were included.
- PRISMA and JADAD criteria were used for article selection and quality assessment, respectively.
Main Results:
- An initial search yielded 932 articles, which were systematically screened and filtered.
- After applying inclusion and exclusion criteria, 7 relevant articles were selected for final review.
- The selected studies consistently indicated a higher prevalence of periodontitis in patients who have experienced a stroke.
Conclusions:
- The evidence suggests a positive association between periodontal disease and stroke.
- Patients with stroke exhibit a greater likelihood of having periodontitis.
- Further research may elucidate the causal mechanisms underlying this relationship.
Abstract:
The aim of this review is to determine if there is a relationship between periodontal disease and stroke. The included case-control and cohort studies mediate the incidence of stroke and periodontal disease by analyzing different parameters. A literature review was carried out in PubMed, Scopus and Embase databases using the key word "stroke" AND "periodontal disease". An amount of 932 articles came out from our research on these three databases. These articles were selected according to PRISMA criteria. The following inclusion criteria were established: studies conducted in humans, articles published in English and published in the last ten years. Exclusion criteria were: experimental studies on animals, articles published more than 10 years ago, non-English language articles, articles of non-indexed journals, and articles not directly related to the association between stroke and periodontitis. These criteria reduced the number of articles from 932 to 399. At the end, articles that appeared to be repeated in different databases have been eliminated: 254 articles remained. All these articles titles were reviewed by the authors, who decided whether or not to include them in the review. We selected an amount of 43 articles. These studies were reviewed by reading the titles and abstracts, and by finally selecting the ones with the same topic of this review. When titles or abstracts were not clear, the complete article was read. At the end 7 articles were selected. In addition, 2 systematic reviews and 1 article, cited in the discussion, and regarding the protocol used in patients suffering from cardiovascular diseases and periodontitis, were selected. The quality of these articles was evaluated through the JADAD system. In conclusion, patients with stroke have a higher prevalence of periodontitis.
More Related Videos
10:11Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies
Published on: October 22, 2014
07:30Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Related Concept Videos
01:26Arteries of the Head and Neck
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
01:15Teeth
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
01:26Coronary Artery Disease II: Pathophysiology
01:21Tooth Anatomy
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
01:27Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation