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Human platelet antigen polymorphisms and the risk of chronic Chagas disease cardiomyopathy

Deborah Elzita do Carmo Corrêa1, Christiane Maria Ayo2, Jeane Eliete Laguila Visentainer1

  • 1Post Graduation Program in Bioscience and Physiopathogy, Department of Clinical Analysis and Biomedicine, Maringá State University, Maringá, Paraná, Brazil.

Platelets
|September 21, 2019
PubMed

Insights

Human platelet antigen (HPA) polymorphisms may influence Chagas disease cardiomyopathy (CCC). The HPA-3 variant appears to protect female patients from severe left ventricular systolic dysfunction (LVSD) in CCC.

Area of Science:

  • Immunogenetics
  • Cardiology
  • Infectious Diseases

Background:

  • Human platelet antigen (HPA) polymorphisms are implicated in cardiovascular and vascular diseases.
  • The specific role of HPA polymorphisms in chronic Chagas disease cardiomyopathy (CCC) remains largely unexplored.
  • Understanding these genetic factors could offer insights into disease progression.

Purpose of the Study:

  • To investigate the association between HPA polymorphisms (HPA-1, -2, -3, -5, and -15) and the severity of left ventricular systolic dysfunction (LVSD) in patients with CCC.
  • To identify potential genetic risk or protective factors influencing CCC progression.

Main Methods:

  • Genotyping of HPA polymorphisms (HPA-1, -2, -3, -5, -15) using PCR-SSP in 229 CCC patients.
  • Classification of patients into groups based on LVSD severity: none, mild/moderate, and severe.
  • Statistical analysis of allele and genotype frequencies using SNPStats software.

Main Results:

  • No statistically significant differences in HPA-1 allele and genotype frequencies were observed across different LVSD severity groups.
  • A significant association was found in stratified analysis: the HPA-3a/3b genotype was less frequent in women with severe LVSD compared to those without LVSD (OR: 0.29; 95% CI: 0.10-0.84).

Conclusions:

  • The HPA-3 variant may act as a protective factor against severe left ventricular systolic dysfunction in female patients with chronic Chagas disease cardiomyopathy.
  • Further research is warranted to confirm the protective role of HPA-3 in this specific patient population.

Keywords:
Chagas diseaseSNPsgenetic association studiesgenotyping techniquehuman platelet antigens

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