Related Experiment Video
Updated: Jan 19, 2026

Live Imaging to Study Microtubule Dynamic Instability in Taxane-resistant Breast Cancers
Published on: February 20, 2017
Taxane-Induced Peripheral Neuropathy: Objective and Subjective Comparison Between Paclitaxel and Docetaxel in
Ya-Ning Chan1, You-Wun Jheng2, Pei-Ju Wang3
1University of North Carolina at Chapel Hill.
Background:
Taxane-induced peripheral neuropathy (TIPN) is caused by the neurotoxicity of paclitaxel and docetaxel, but the differences between paclitaxel- and docetaxel-induced peripheral neuropathy are understudied.
Objectives:
The purpose of this study is to compare TIPN between docetaxel and paclitaxel in patients with breast cancer and to examine the consistency of measuring TIPN between researchers and patients.
Methods:
Secondary data were analyzed from a cross-sectional study that included 64 patients with breast cancer from two teaching hospitals in Taiwan. Objective and subjective TIPN were measured.
Findings:
Results indicated significant differences in objective TIPN, sensory sum score, and motor sum score between groups. No significant difference was detected in subjective TIPN between groups.
Related Concept Videos
Drugs that Stabilize Microtubules
Local Anesthetics: Differential Sensitivity of Nerve Fibers
Peripheral Artery Disease IV: Nursing Management
Peripheral Artery Disease V: Postoperative Nursing Management
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

