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Updated: Jan 19, 2026

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A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
Published on: May 22, 2018
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Cu2+ Effects on Beta-Amyloid Oligomerisation Monitored by the Fluorescence of Intrinsic Tyrosine
Abeer Alghamdi1, Thorben Wellbrock1, David J S Birch1
1Department of Physics, University of Strathclyde, Glasgow, G4 0NG, UK.
Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry
|September 21, 2019
Abstract:
A non-invasive intrinsic fluorescence sensing of the early stages of Alzheimer's beta amyloid peptide aggregation in the presence of copper ions is reported. By using time-resolved fluorescence techniques the formation of beta amyloid-copper complexes and the accelerated peptide aggregation are demonstrated. The shifts in the emission spectral peaks indicate that the peptides exhibit different aggregation pathways than in the absence of copper.

