Oxidation of Tetrahydro-β-carbolines by Persulfate
Haijun Chen1, Fu Ye1, Jing Luo1
1Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry , Fuzhou University , Fuzhou , Fujian 350116 , China.
Abstract:
The development of persulfate-mediated oxidation of tetrahydro-β-carbolines is reported. This mild reaction facilitates the formation of a variety of 2-formyl N-substituted tryptamines and the related derivatives as key intermediates in moderate to excellent yields. The method is applicable to direct last-stage oxidation of two interesting pharmaceuticals, Cialis and evodiamine.
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