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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
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Finite Element Driven Design Domain Identification of a Beating Left Ventricular Simulator.

Utku Gulbulak1, Atila Ertas2

  • 1Department of Mechanical Engineering, Texas Tech University, Lubbock, TX 79409, USA. utku.gulbulak@ttu.edu.

Bioengineering (Basel, Switzerland)
|September 22, 2019
PubMed
Summary

This study optimized a left ventricular assist device simulator. A finite element analysis identified 4 mm wall thickness and 8 actuators at 90 degrees for improved heart simulation performance.

Keywords:
finite element modelleft ventricular assist devicesleft ventricular simulatorparametric study

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Device Development
  • Computational Mechanics

Background:

  • Heart disease affects nearly 10% of Americans, necessitating advanced treatments like left ventricular assist devices (LVADs).
  • In-vitro mock circulation studies are vital for LVAD development, requiring accurate heart simulators.
  • Existing beating left ventricular simulators have shown limitations in flow rate.

Purpose of the Study:

  • To optimize the design of a beating left ventricular simulator using a finite element-driven approach.
  • To identify optimal parameters for wall thickness, actuator number, and actuator orientation for enhanced deformation.
  • To improve the performance of simulators used in left ventricular assist device development.

Main Methods:

  • Development and validation of a nonlinear finite element model of the beating left ventricular simulator.
  • Creation of a design domain comprising 150 finite element models with varied parameters.
  • Systematic variation of wall thickness, number of McKibben actuators, and their helical orientation angle.

Main Results:

  • The finite element analysis identified specific design parameters for improved simulator performance.
  • A combination of 4 mm wall thickness and 8 actuators with a 90-degree orientation angle yielded the best deformation.
  • This optimized configuration significantly enhances the simulator's ability to mimic cardiac function.

Conclusions:

  • Finite element analysis is effective for optimizing complex biomedical device designs.
  • The identified optimal parameters provide a pathway for developing more efficient and accurate left ventricular assist device simulators.
  • Improved simulator performance can accelerate the development and validation of life-saving cardiovascular technologies.